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本文用紫外分光光度计二阶导数光谱法测定6名健康志愿受试者(?)单剂量po氧氟沙星国产、进口两种片剂后的尿药浓度,进行药物动力学和生物利用度研究。国产和进口氧氟沙星片药物动力学参数分别为:T1╱2:7.41±1.44和7.41±1.07(h),K:0.0978±0.03和0.0971±0.02(h-1),相对生物利用度为99.57％
Abstract：The paper reported the determination of ofloxacin in urine by second derivative spectrophotometry. Pharmacokinetics and bioavailability of ofloxacin were studied in 6 healthy volunteers after oral administration, and a comparison was made between different tablets come from home and Japah. Pharmacokinetic parameters of the two ofloxacins were: T1/2: 7. 4 ± 1. 44 and 7. 4± 1. 07 (h) ; K: 0.0978 + 0.03 and 0. 0971±0. 02(h-1); comparative bioavailability was 99. 57%,
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基本信息:
DOI：10.19577/j.cnki.issn10074406.1994.03.003
中图分类号:R96
引用信息:
[1]陈焰,宋钟娟,童如镜.紫外二阶导数光谱尿药法比较氧氟沙星两种片剂的生物利用度[J].临床药学,1994(03):8-10.DOI:10.19577/j.cnki.issn10074406.1994.03.003.
1994-09-30
1994-09-30