中国临床药学杂志

目的探讨缬沙坦联合氨氯地平对老年性高血压左心室肥厚及构型的影响。方法将70例高血压患者分成2组,Ⅰ组(n=38)予以缬沙坦联合氨氯地平;Ⅱ组(n=32)单用氨氯地平,2组均给药6 mo后,行24 h动态血压监测(ABPM)和超声心动图检查。结果2组24 h ABPM参数24 h SBP、24 h DBP、dSBP、dDBP、nSBP、nDBP和心脏彩色超声参数IVST、RWT、INMI用药后均较用药前有显著下降,但Ⅰ组优于Ⅱ组(P<0．05)。结论缬沙坦联合氨氯地平在逆转高血压左室肥厚方面有协同作用,且左室构型中向心性重构是防止心肌损害加重的关键阶段。

AIM To explore the effect of combining valsartan with amlodipine on hypertrophy and left ventricular pattern (LVP) in elderly essential hypertension (EH). METHODS Seventy hypertensive patients were randomly assigned intoby 2 groups. GroupⅠ( n = 38) was treated with both valsartan and amlodipine, and groupⅡ( n = 32) was treated with amlodipine only. After 6 mo,the examination of ultrasonic cardiogram was made into by 24 h ABPM and E-chocardiography. RESULTS The parameters of 24 h ABPM (24 h SBP, 24 h DBF, dSBP, dDBP, nSBP, nDBP) and color echocardiography ( IVST,RWT,LVMI) after treatment in the 2 groups were significantly decreased as compared with those before treatment respectively. However, the combination group was markedly superior to amlodipine group (P < 0.05) . CONCLUSION Valsartan combining with amlodipine has synergistic effect on regressing LVP in EH. To conjecture the concentric remodeling is the key stage in preventing the heart from deteriorating.