| 68 | 2 | 25 |
| 下载次数 | 被引频次 | 阅读次数 |
目的:探讨蚯蚓提取物对原发性肾小球疾病中凝血、抗凝、纤溶功能及血液流变学的影响.方法:对36例原发性肾病综合征和30例慢性肾小球肾炎给予po蚯蚓提取物150mg/次,tid,连用14d,在用药前后采血测定凝血、抗凝、纤溶及血液流变学指标.结果:治疗后血KPTT、PT、TT较治疗前明显延长(P<0.01、P<0.05),AT-Ⅲ及t-PA活性在治疗后较治疗前明显升高(P<0.001,P<0.01),FDP含量较治疗前也明显上升(P<0.01),血液流变学指标较治疗前均有显著改善(P<0.05、P<0.01).结论:蚯蚓提取物具有抗凝、纤溶的功能,po蚯蚓提取物能改善肾小球疾病的高凝状态.
Abstract：AIM:To explore the influence of earthworm extract on coagulation,anticagu-lation,fibrinolysis and blood viscosity of primary glomerular disease. METHODS:Thirty-six cases of primary nephrotic symdrone (PNS)and 30 cases of chronic glomerulonephrtis (CGN) were given earthworm extract 150 mg/time ,tid,for 14 d. The parameters of coagulation .anticoagulation. fibrinolysis and blood viscosity were measured before and after treatment. RESULTS: KPTT, PT, TT were prolonged markedly after treatment (P<0.01,P< 0. 05). The activity of AT-III t-PA were increased markedly after treatment (P<0. 01,P< 0. 01). Fibrinogen was lower markedly(P<0. 05)than that before treatment. All the parameters of blood viscosity were changed markedly after treatment (P<0. 05,P<0. 01). CONCLUSION : Earth worm extract has the effect of anticoagulation and fibrinolysis. Hypercoagu-lated state of glomerular disease was improved after given,po,earthworm extract.
[1]王鸿利.肾小球疾病中的凝血障碍.见:董德长主编,内科疾病的肾脏表现(第2版)北京:人民卫生出版社,1996:298～329
[2]Rober A,Kitera J,Broteory EG,et al.Clinical correlation betwen hypercoagulability and thromboetic phenomenon.Thromb Res,1994.74:125
[3]Levin EG,Naragaj GR,Takiee T,et al.Latent tissue plasminogen activator produced by human endothelial cells in culture:Evidence for an enzymeinhibitor complex.Proc Natl Acad Sci USA,1996,93:6804
[4]Nilsson IM, Nisch R,Fox JW f,et al.Two different macha-nisms in patients with venous thrombosis and defective fibrinolysis:Low concentration of plasminogen activator or increased concentration of plasminogen activator inhibitor.Br Med J,1995,310:2053
[5]Tomura S,Nakamura Y,Deguchi F,et al.Coagulation and fibrinolysis in patients with chronic renal failure and undergoing conservative trcatment.Thromb Res,1991,64:81
[6]Park K,Kye C,Lee M, et al.Fibrinolytic activity of the earthworm extract.Throm Haemost,1989,62(1):689
[7]Mihara H, Fine LJ,Okuda S,et al.A possibility of earthworm powder as therapeutic agent for thrombosis.Thromb Haemost,1989,62(1):545
基本信息:
DOI：10.19577/j.cnki.issn10074406.1999.06.011
中图分类号:R277.5
引用信息:
[1]邵凤民,张小玲,程银桢,王小阳,朱长连,邢清和,张明轩.蚯蚓提取物治疗原发性肾小球疾病高凝状态[J].中国临床药学杂志,1999(06):363-365.DOI:10.19577/j.cnki.issn10074406.1999.06.011.
1999-12-15
1999-12-15