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2023, 11, v.32 865-873
药物神经毒性的评价模型及应用
基金项目(Foundation): 国家自然科学基金(编号82173896)
邮箱(Email): zhangj_fudan@aliyun.com;
DOI: 10.19577/j.1007-4406.2023.11.012
发布时间: 2023-11-25
出版时间: 2023-11-25
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摘要:

药物神经毒性是指由药物引起的对神经系统功能和/或结构的损害。神经毒性是药物不良反应之一,也是药物临床前安全性评价的重要方面。一般来说,研究和评价神经毒性的模型主要指体外模型和体内模型。体外模型包括二维单细胞培养(神经细胞系、原代神经细胞和神经干细胞),三维多细胞培养(再聚集脑细胞),以及器官型培养(类器官、器官芯片)等。体内模型包括传统的哺乳动物模型和非哺乳动物模型。非哺乳动物模型由于其结构简单、操作方便也逐渐被广泛地用于神经毒性评价,主要包括线虫、斑马鱼、果蝇等。仅靠单一体内模型或体外模型无法完整全面地评价药物神经毒性,因此对于不同的药物,需要选择合适的方法及模型组合进行综合评价,才能得出准确可靠的结论。

Abstract:

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参考文献

[1]STAFF N P,GRISOLD A,GRISOLD W,et al.Chemotherapyinduced peripheral neuropathy:a current review[J].Ann Neurol,2017,81(6):772.

[2]FRIT SCHE E,TIGGES J,HARTMANN J,et al.Neural in vitro models for studying substances acting on the central nervous system[J].Handb Exp Pharmacol,2021,265:111.

[3]PELLACANI C,ELEFTHERIOU G.Neurotoxicity of antineoplastic drugs:mechanisms,susceptibility,andneuroprotective strategies[J].Adv Med Sci,2020,65(2):265.

[4]MONTANA M C,EVERS A S.Anesthetic neurotoxicity:new findings and future directions[J].J Pediatr,2017,181:279.

[5]张晓燕,刘宁,王彦红.临床常用药物的神经毒性[J].山东医药,2014,54(1):101.

[6]DAI C S, XIAO X L,LI J C,et al.Molecular mechanisms of neurotoxicity induced by polymyxins and chemoprevention[J].ACS Chem Neurosci,2019,10(1):120.

[7]PAYNE L E,GAGNON D J,RIKER R R,et al.Cefepime-induced neurotoxicity:a systematic review[J].Crit Care,2017,21(1):276.

[8]BAL-PRICE A K,SUNOL C,WEISS D G,et al.Application of in vitro neurotoxicity testing for regulatory purposes:SymposiumⅢsummary and research needs[J].Neurotoxicology,2008,29(3):520

[9]屈哲.减毒活疫苗及神经毒性药物评价体外替代方法的应用[D].北京:中国农业大学,2017.

[10]CHEUNG Y T,LAU W K, YU M S, et al.Effects of all-transretinoic acid on human SH-SY5Y neuroblastoma as in vitro model in neurotoxicity research[J].Neurotoxicology,2009,30(1):127.

[11]LOPEZ-SUAREZ L.AWABDH S A, COUMOUL X,et al.The SHSY5Y human neuroblastoma cell line,a relevant in vitro cell model for investigating neurotoxicology in human:focus on organic pollutants[J].Neurotoxicology,2022,92:131.

[12]POPOVA D,KARLSSON J,JACOBSSON S O P.Comparison of neurons derived from mouse P19,rat PC 12 and human SHSY5Y cells in the assessment of chemical-and toxin-induced neurotoxicity[J].BMC Pharmacol Toxicol,2017,18(1):42.

[13]ASCHNER M,SYVERSEN T.Neurotoxicology:principles and considerations of in vitro assessment[J].Altern Lab Anim,2004.32(4):323.

[14]SCIARRETTA C,MINICHIELLO L.The preparation of primary cortical neuron cultures and a practical application using immunofluorescent cytochemistry[J].Methods Mol Biol,2010,633:221.

[15]SILVA R F.FALCAO A S,FERNANDES A,et al.Dissociated primary nerve cell cultures as models for assessment of neurotoxicity[J].Toxicol Lett,2006,163(1):1.

[16]田康,黄芝瑛,王雪,等.药物神经毒性评价体外模型的研究进展[J].药物评价研究,2020,43(7):1433.

[17]LIU Y X,LO Y C, QIAN L,et al.Verapamil protects dopaminergic neuron damage through a novel anti-inflammatory mechanism by inhibition of microglial activation[J].Neuropharmacology,2011,60(2-3):373.

[18]WU J,YANG J J,CAO Y,et al.Iron overload contributes to general anaesthesia-induced neurotoxicity and cognitive deficits[J].J Neuroinflammation,2020,17(1):110.

[19]GROCHOWSKI C,RADZIKOWSKA E,MACIEJEWSKI R.Neural stem cell therapy-Brief review[J].Clin Neurol Neurosurg,2018,173:8.

[20]MING G L,SONG H J.Adult neurogenesis in the mammalian brain:significant answers and significant questions[J].Neuron,2011,70(4):687.

[21]王美婷,张艺哲,邢红艳,等.人源性干细胞分化的神经细胞在药物神经毒性评价中的应用[J].中国医药工业杂志,2021,52(5):611.

[22]TUKKER A M.DE GROOT M W,WIJNOLTS F M,et al.Is the time right for in vitro neurotoxicity testing using human iPSCderived neurons?[J].ALTEX,2016,33(3):261.

[23]COLAIANNA M,ILMJARV S,PETERSON H,et al.Fingerprinting of neurotoxic compounds using a mouse embryonic stem cell dual luminescence reporter assay[J].Arch Toxicol,2017,91(1):365.

[24]WILSON M S,GRAHAM J R,BALL A J.Multiparametric High Content Analysis for assessment of neurotoxicity in differentiated neuronal cell lines and human embryonic stem cell-derived neurons[J].Neurotoxicology,2014,42:33.

[25]ESKES C,JUILLERAT-JEANNERET L,LEUBA G,et al.Involvement of microglia-neuron interactions in the tumor necrosis factor-alpha release,microglial activation,and neurodegeneration induced by trimethyltin[J].J Neurosci Res.2003,71(4):583.

[26]ZURICH M G,HONEGGER P.SCHILTER B,et al.Involvement of glial cells in the neurotoxicity of parathion and chlorpyrifos[J].To xicol Appl Pharmacol,2004,201(2):97.

[27]VAN VLIET E,STOPPINI L,BALESTRINO M,et al.Electrophysiological recording of re-aggregating brain cell cultures on multi-electrode arrays to detect acute neurotoxic effects[J].Neurotoxicology,2007,28(6):1136.

[28]KO K R,TSAI M C,FRAMPTON J P.Fabrication of thin-layer matrigel-based constructs for three-dimensional cell culture[J].Biotechnol Prog,2019,35(1):e2733.

[29]KO K R,TAM N W,TEIXEIRA A G,et al.SH-SY5Y and LUHMES cells display differential sensitivity to MPP+,tunicamycin,and epoxomicin in 2D and 3D cell culture[J].Biotechnol Prog,2020,36(2):e2942.

[30]CLEVERS H.Modeling development and disease with organoids[J].Cell,2016,165(7):1586.

[31]CORRòC,NOVELLASDEMUNT L,LI V S W.A brief history of organoids[J].Am J Physiol Cell Physiol,2020,319(1):C151.

[32]AUGUSTYNIAK J,BERTERO A,COCCINI T,et al.Organoids are promising tools for species-specific in vitro toxicological studies[J].J Appl Toxicol,2019,39(12):1610.

[33]LEE C T,BENDRIEM R M,WU W W,et al.3D brain Organoids derived from pluripotent stem cells:promising experimental models for brain development and neurodegenerative disorders[J].J Biomed Sci,2017,24(1):59.

[34]HU W T,WANG C L,GAO D,et al.Toxicity of transition metal nanoparticles:a review of different experimental models in the gastrointestinal tract[J].J Appl Toxicol,2023,43(1):32.

[35]MAREI I,ABU SAMAAN T,AL-QURADAGHI M A,et al.3D tissue-engineered vascular drug screening platforms:promise and considerations[J].Front Cardiovasc Med,2022,9:847554.

[36]MUGURUMA K,NISHIYAMA A,KAWAKAMI H,et al.Selforganization of polarized cerebellar tissue in 3D culture of human pluripotent stem cells[J].Cell Rep,2015,10(4):537.

[37]JO J, XIAO Y X,SUN A X,et al.Midbrain-like organoids from human pluripotent stem cells contain functional dopaminergic and neuro melanin-producing neurons[J].Cell Stem Cell,2016,19(2):248.

[38]SAKAGUCHI H,KADOSHIMA T,SOEN M,et al.Generation of functional hippocampal neurons from self-organizing human embryonic stem cell-derived dorsomedial telencephalic tissue[J].Nat Common,2015,6:8896.

[39]LIU F K,HUANG J,LIU Z X.Vincristine impairs microtubules and causes neurotoxicity in cerebral organoids[J].Neuroscience,2019,404:530.

[40]LANCASTER M A,RENNER M,MARTIN C A,et al.Cerebral organoids model human brain development and microcephaly[J].Nature,2013,501(7467):373.

[41]CAKIR B,XIANG Y F,TANAKA Y,et al.Engineering of human brain organoids with a functional vascular-like system[J].Nat Methods,2019,16(11):1169.

[42]CHIARADIA L,LANCASTER M A.Brain organoids for the study of human neurobiology at the interface of in vitro and in vivo[J].Nat Neurosci,2020,23(12):1496.

[43]MATSUI T,SHINOZAWA T,Human organoids for predictive toxicology research and drug development[J].Front Genet,2021,12:767621.

[44]YEO L Y.CHANG H C,CHAN P P,et al.Microfluidic devices for bioapplications[J].Small,2011,7(1):12.

[45]ZHUANG Q C,NING R Z, MA YA,et al.Recent developments in microfluidic chip for in vitro cell-based research[J].Chin J Anal Chem,2016,44(4):522.

[46]VOLPATTI L R,YETISEN A K.Commercialization of microfluidic devices[J].Trends Biotechnol,2014,32(7):347.

[47]ZHANG B Y,KOROLJ A,LAI B F L,et al.Advances in organ-ona-chip engineering[J].Nat Rev Mater,2018,3(8):257.

[48]PARK S E,GEORGESCU A,HUH D.Organoids-on-a-chip[J].Scierice,2019,364(6444):960.

[49]MAHER M,WRIGHT J,PINE J,et al.A microstructure for interfacing with neurons:the neurochip[C]//Proceedings of the20th Annual International Conference of the IEEE Engineering in Medicine and Biology Society.Vol.20 Biomedical Engineering Towards the Year 2000 and B eyond(Cat.No.98CH36286).November 1-1, 1998,Hong Kong,China.IEEE,2002:1698.

[50]KANG W,GIRALDO-VELA J P,NATHAMGARI S S,et al.Microfluidic device for stem cell differentiation and localized electroporation of postmitotic neurons[J].Lab Chip,2014,14(23):4486.

[51] WANG Y Q,WANG L,ZHU Y J,et al.Human brain organoid-ona-chip to model prenatal nicotine exposure[J].Lab Chip,2018,18(6):851.

[52]CONG Y,HAN X H,WANG Y P,et al.Drug toxicity evaluation based on organ-on-a-chip technology:a review[J].Micromachines,2020,11(4):381.

[53]SEO Y,BANG S,SON J,et al.Brain physiome:a concept bridging in vitro 3D brain models and in silico models for predicting drug toxicity in the brain[J].Bioact Mater,2022,13:135.

[54]The guidelines of the Organisation for Economic Cooperation and Development.[J].2007,(Test No 424 neurotoxicity study in rodents Test No.426:DevelopmentalNeurotoxicity Study).

[55]BOYES W K, DOURSON M L,PATTERSON J,et al.EPA's neurotoxicity risk assessment guidelines[J].Fundam Appl Toxicol,1997,40(2):175.

[56]QUESNE P M.Principles and methods for the assessment of neurotoxicity associated with exposure to chemicals,(environmental health criteria No60.)[J].J Neurol Neurosurg&Psychiatry,1987,50:510.

[57]HARRIS J.Experimental and clinical neurotoxicology,2nd edition[J].J Neurol Neurosurg&Psychiatry,2001,70:421.

[58]KRINKE G J.Neuropathologic screening in rodent and other species[J].J Am Coll Toxicol.1989,8(1):141.

[59]GRIFFIN J W.Basic pathologic processes in the nervous system[J].Toxicol Pathol,1990,18(1 Pt 2):83.

[60]DYER R S.The use of sensory evoked potentials in toxicology[J].Fundam Appl Toxicol,1985,5(1):24.

[61]REBERT C S.Multisensory evoked potentials in experimental and applied neurotoxicology[J].Neurobehav Toxicol Teratol,1983,5(6):659.

[62]BO YES W K,Sensory-evoked potentials:measures of neurotoxicity[J].NIDARes Monogr,1993,136:63.

[63]MINA S G,ALAYBEYOGLU B,MURPHY W L,et al.Assessment of drug-induced toxicity biomarkers in the brain microphysiological system(MPS)using targeted and untargeted molecular profiling[J].Front Big Data,2019,2:23.

[64]ANGER W K.Neurobehavioral testing of chemicals:impact on recommended standards[J].Neurobehav Toxicol Teratol,1984,6(2):147.

[65]TIL SON H A.Behavioral indices of neurotoxicity:what can be measured?[J].Neurotoxicol Teratol,1987,9(6):427.

[66]TILSON H A,MOSER V C.Comparison of screening approaches[J].Neurotoxicology,1992,13(1):1.

[67]CARR R L,CHAMBERS J E.Acute effects of the organophosphate paraoxon on schedule-controlled behavior and esterase activity in rats:dose-response relationships[J].Pharmacol Biochem Behav,1991,40(4):929.

[68]VON AULOCK S.Alternatives to animal experiments[J].ALTEX,2014,31(2):U2.

[69]PETERSON R T,NASS R, BOYD W A,et al.Use of nonmammalian alternative models for neurotoxicological study[J].Neurotoxicology,2008,29(3):546.

[70]王亚辉.秀丽隐杆线虫(Caenorhabditis elegans):一个研究神经系统的最简单模型[J].中国神经科学杂志,2000,16(1):60.

[71]QUEIROS L,PEREIRA J L,GON?ALVES F J M,et al.Caenorhabditis elegans as a tool for environmental risk assessment:emerging and promising applications for a"nobelized worm"[J].Crit Rev Toxicol,2019,49(5):411.

[72]WHITE J G,SOUTHGATE E,THOMSON J N,et al.The structure of the nervous system of the nematodeCaenorhabditis elegans[J].Phil Trans R Soc Lond B,1986,314(1165):1.

[73]WELLENBERG A,BRINKMANN V, BORNHORST J,et al.Cisplatin-induced neurotoxicity involves the disruption of serotonergic neurotransmission[J].Pharmacol Res,2021,174:105921.

[74]HORZMANN K A,FREEMAN J L.Zebrafish get connected:investigating neurotransmission targets and alterations in chemical toxicity[J].Toxics,2016,4(3):19.

[75]WULLIMANN M F,MUELLER T.Teleostean and mammalian forebrains contrasted:evidence from genes to behavior[J].J Comp Neurol,2004,475(2):143.

[76]WULLIMANN M F.Secondary neurogenesis and telencephalic organization in zebrafish and mice:a brief review[J].Integr Zool, 2009,4(1):123.

[77]ZHAO Y M,YANG Q X,LIU D,et al.Neurotoxicity of nanoparticles:insight from studies in zebrafish[J].EcotoxicolEnviron Saf,2022,242:113896.

[78]BERTOTTO L B,CATRON T R,TAL T.Exploring interactions between xenobiotics,microbiota,and neurotoxicity in zebrafish[J].Neurotoxicology,2020,76:235.

[79]CHENG B,JIANG F,SU M L,et al.Effects of lincomycin hydrochloride on the neurotoxicity of zebrafish[J].Ecotoxicol Environ Saf,2020,201:110725.

[80]WU Z H,DU Y M,XUE H,et al.Aluminum induces neurodegeneration and its toxicity arises from increased iron accumulation and reactive oxygen species(ROS)production[J].Neurobiol Aging,2012,33(1):199.e1.

[81]OGUNSUYI O B,OLAGOKE O G,AFOLABI B A,et al.Dietary inclusions of Solanum vegetables mitigate aluminum-induced redox and inflammation-related neurotoxicity in Drosophila melanogaster model[J].Nutr Neurosci,2022,25(10):2077.

[82]HIRTH F,Drosophila melanogaster in the study of humanneurodegeneration[J].CNS Neurol Disord Drug Targets,2010,9(4):504.

[83]GROEN C M,PODRATZ J L,TREB K,et al.Drosophila strain specific response to cisplatin neurotoxicity[J].Fly,2018,12(3-4):174.

[84]PODRATZ J L,STAFF N P,FROEMEL D,et al.Drosophila melanogaster:a new model to study cisplatin-induced neurotoxicity[J].Neurobiol Dis,2011,43(2):330.

[85]CIRRINCIONE AM,RIEGER S.Analyzing chemotherapy-induced peripheral neuropathy in vivo using non-mammalian animal models[J].Exp Neurol,2020,323:113090.

[86]SCHULTZ L,ZURICH M G,CULOT M,et al.Evaluation of druginduced neurotoxicity based on metabolomics,proteomics and electrical activity measurements in complementary CNS in vitro models[J].Toxicol In Vitro,2015,30(1 Pt A):138.

基本信息:

DOI:10.19577/j.1007-4406.2023.11.012

中图分类号:R969

引用信息:

[1]奚琳,卞星晨,吴俊珍,等.药物神经毒性的评价模型及应用[J].中国临床药学杂志,2023,32(11):865-873.DOI:10.19577/j.1007-4406.2023.11.012.

基金信息:

国家自然科学基金(编号82173896)

发布时间:

2023-11-25

出版时间:

2023-11-25

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