nav emailalert searchbtn searchbox tablepage yinyongbenwen piczone journalimg journalInfo journalinfonormal searchdiv searchzone qikanlogo popupnotification paper paperNew
1998, 02, 93-98
硝酸异山梨酯缓释剂的作用机制、耐药性及临床应用
基金项目(Foundation):
邮箱(Email):
DOI: 10.19577/j.cnki.issn10074406.1998.02.017
摘要:

<正>硝酸酯(nitrates)用于治疗心脏疾病已有一百余年的历史,常用的有硝酸甘油(ni-troglycerin)、硝酸异山梨酯(isosorbide dini-trate,ISDN)、单硝酸异山梨酯(isosorbidemononitrate,ISMN)等.硝酸甘油于1847年由Sombrero等合成,有机硝酸酯类出现于本世纪30年代.硝酸异山梨酯于1946年在瑞典上市(商品名为Harrical,剂型为片剂和软膏),50年代美国化学家也独立合成了IS- DN,在美国上市的商品名为Isordil.此后,ISDN在全世界被广泛应用.

关键词:
Abstract:

KeyWords:
参考文献

[1]Berlin R.Historical aspects of nitrate therapy.Drugs1987,33(Supp14):1

[2]Ahlner J,Axelsson KL.Nitrates mode of action at a cellular level.Drugs 1987,33(Suppl.4):32

[3]Parker JA.Organic nitrates:new formulations and their clinical advantages.Am J Cardiol 1996,77:38

[4]饶蔓人.抗心肌缺血药.见:心血管药理学(主编:陈修).北京:人民卫生出版社,1997:406~408

[5]Li WJ.Kitakaze M,Minamino T,et al.Nitrate oxide opens the seconds windows of cardioprotection of ischemic preconditioning:role of induction of heat shoek protein(HSP72).J Am College Cardiol 1997,29(2,Supple):12A

[6]Parker JO.Nitrate tolerance-can it be prevented? Eur Heart J 1991,12(Suppl A):13

[7]Parker JD,Farrell B,Parker AC,et al.Neurohumoral responses and the hemodynamic adaptation to nitrates.Circulation 1990,82(Suppl Ⅱ):Ⅱ-214

[8]Parkcr JO.Update on nitrate tolerance.Br J Clin Pharmacol 1992,34:11S

[9]Rudolph W,Dirschingcr J,Reiniger G,et al.When dose nitrate tolerance develop?What dosages and which intervals are necessary to ensure maintained effectiveness?Eur Heart J 1988,9(Suppl A):63

[10]Silber S,Vogler AC,Krausc KH,et al.The haemodynamic and anti-ischaemic effects of a single tablet of 80mg isosorbide dintrate in slow-release formulation and a review of nitrate tolerance.Drugs 1987,33(Supp1.4):69

[11]Silber S,Vogler AC,Krause KH,et al.Induction and circumvention of nitrate tolerance applying different dosage interrals.Am J Med 1987,83:860

[12]Parker JO,Baird MG.Efficacy of cecentric dosing with sustained-release isosorbide dinitrate in patients with angina pectoris.Can J Cardiol 1994,10(9):909

[13]Dubiel JP,Moczurad KW,Bryniarski L.Efficacy of a single dose of slow-relcase isosorbide dinitrate in the treatment of silent or painful myocardial ischaemia in stable angina pectoris.Am J Cardiol 1992,69(1):1156

[14]Aschermann M,Bultas J,Karetova D,et al.Randomized double-blind comparison of isosorbide dinitrate and nifedipine in variant angina pectoris.Am J Cardiol 1990,65(21):46J

[15]Rao YV,Reddy KS,Wasir HS.Assessment of antianginal efficacy of long-acting sustained release isosorbide dinitrate in comparison with short-acting isosorbide dinitrate.India Heart J 1991,43(2):97

[16]Lalla JK,Bhat SH,Girappanavar DM.Controlled-release isosorbide dinitrate pellets.Part 2:in vivo studies.J Pharmaceutical Sci 1993,82(12):1292

[17]Henning L,Andresen D,Hennig A,et al.Comparison of the effect of isosorbide-5-mononitrate and isosorbide dinitrate in a slow-release form on excreise-induced myo-cardial ischaemia.J Clin Pharmacol 1991,31:636

[18]Friedensohn A,Meshulam R,Schlesinger Z.Randomized double-blind comparison of the effects of isosorbide dinitrate retard,verapamil sustained-release,and their combination myocardial ischemic episodes.Cardiology 1991,79(Suppl 2):31

[19]Lehmann G,Reiniger G,Haase HU,et al.Enhanced effectiveness of combined sustained-release forms of isosorbide dinitrate and diltiszem for stable angina pectoris.Am J Cardiol 1991,68(10):983

[20]Dubourg O,Gueret P,Ferrier A,et al.Controlled,eighthour haemodynamic study of a sustained-release formation of isosorbide dinitrate in moderate left ventricular failure.Eur J Clin Pharmacol 1984,27(3):259

[21]Wolf R,Notges A,Traber U.Hcmodynamic effect of subchronic therapy with 120 mg isosorbide dinitrate in a slow release form in minimal to moderate post-infaret heart failurc.Z Kardiol 1989,78(Suppl 2):137

[22]Duchier J,Inannascoli F,Safar M.Antihypertensive effeet of sustained-release isosorbide dinitrate for isolated systolic systemic hypertension in the eldcrly.Am J Cardiol 1987,60:99

[23]Cervinka J,Kordac V,Kalab M.Effect of peroral administration of isosorbide dinitrate on portal pressure and blood flow in patients with cirrhosis of the liver.J Int Med Res 1989,17(6):560

基本信息:

DOI:10.19577/j.cnki.issn10074406.1998.02.017

中图分类号:R96

引用信息:

[1]李静,程务本.硝酸异山梨酯缓释剂的作用机制、耐药性及临床应用[J].中国临床药学杂志,1998(02):93-98.DOI:10.19577/j.cnki.issn10074406.1998.02.017.

发布时间:

1998-04-15

出版时间:

1998-04-15

检 索 高级检索

引用

GB/T 7714-2015 格式引文
MLA格式引文
APA格式引文