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目的：研究Ｎ－乙酰半胱氨酸（ＮＡＣ）对缓解期肺心病的抗氧化和免疫调节作用。方法：３８例肺心病缓解期患者予ＮＡＣ ６００ ｍｇ．ｐｏ，ｑｄ，共６ｍｏ。比较治疗前和治疗后１，３，６ｍｏ血清ＭＤＡ，ＣＤ３，ＣＤ４，ＣＤ８水平，并与健康志愿者（对照组）比较。结果：与对照组比较肺心病缓解期ＭＤＡ明显升高（Ｐ＜０．０５），而ＣＤ４显著降低（Ｐ＜０．０１）；经ＮＡＣ治疗后ＭＤＡ、ＣＤ４分别于１，３ｍｏ月恢复正常。结论：ＮＡＣ能降低肺心病缓解期患者的过氧化物水平，捉高免疫力，有可能减少急性加重的发生。
Abstract：AIM: To study the effect of anti-oxidation and immunity adjustment of N-acetylcysteine (NAC) on patients in remission stage with cor pulmonales. METHODS: Thirty-eight patients in remission stage with cor pulmonales were treated with NAC 600 mg, pa, qd, and the serum MBA, CD3, CD4, CD8 contents between treat group before and after 1, 3, 6 mo after treatment as well as control group was com- pared, to observe frequency of the exacerbation in 6 mo. RESULTS: Serum MDA content was higher (P< 0.05), CD4 content was lower (P<0. 01) in patients in remission stage with cor pulmonales than that in control group; content of MDA and CD4 returned to normal level after 1st, 3rd month with NAC treat- ment. The frequency of the exacerbation was decreased significantly. CONCLUSION: NAC can reduce the lipid peroxide, improve the immunity function and decrease the frequency of the exacerbation in patients with cor pulmonales in remission stage.
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基本信息:
DOI：10.19577/j.cnki.issn10074406.2001.05.002
中图分类号:R541.5
引用信息:
[1]毕筱刚,李建国,周凤丽,张天托,张扣兴.N-乙酰半胱氨酸对缓解期肺心病的抗氧化和免疫调节作用[J].中国临床药学杂志,2001(05):275-276.DOI:10.19577/j.cnki.issn10074406.2001.05.002.
2001-10-25
2001-10-25