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呋喹替尼(fruquintinib)是一种有效的、高选择性、可口服的血管内皮细胞生长因子受体(VEGFR)-1,2,3酪氨酸激酶抑制剂,可以抑制血管内皮生长因子(VEGF)诱导的VEGFR-2磷酸化、内皮细胞增殖和小管形成,用于治疗既往对二线以上化疗无效的晚期转移性结直肠癌。然而,呋喹替尼也存在许多不良反应,如高血压、蛋白尿和手足综合征等,因此,在治疗期间需密切关注高危人群的不良反应的发生。该综述回顾了呋喹替尼作为单一疗法或与其他药物联合治疗转移性结直肠癌时所引发的不良事件,并对其管理策略进行深入探讨,旨在为接受呋喹替尼治疗的结直肠癌患者提供针对性的预防和不良反应管理指南,以优化治疗过程并提高患者的生活质量。
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基本信息:
DOI:10.19577/j.1007-4406.2024.08.017
中图分类号:R735.34;R969
引用信息:
[1]刘翾,袁梅琴,王增.呋喹替尼治疗转移性结直肠癌的安全性研究进展[J].中国临床药学杂志,2024,33(08):635-640.DOI:10.19577/j.1007-4406.2024.08.017.
基金信息:
浙江省医药卫生一般研究计划项目(编号2023KY564); 浙江省中医药科技计划项目(编号2022ZB052)
2024-08-25
2024-08-25