中国临床药学杂志

目的探讨心理异常与头痛发作的可能关系,并观察氟哌噻吨-美利曲辛对伴焦虑抑郁头痛发作的疗效。方法采用焦虑自评量表(SAS)及汉密尔顿抑郁量表(HAMD)对头痛患者及健康体检者(对照组)进行心理测评,比较2组焦虑、抑郁的发生率。随机将心理测评异常的头痛患者(73例)分为常规组(36例)和综合组(37例)。常规组予头痛的常规治疗(尼莫地平20mg,po,tid;阿司匹林25mg,po,qd),综合组在此基础上加用氟哌噻吨-美利曲辛1粒,po,qd。疗程均为8wk。结果82例头痛患者中73例伴焦虑或抑郁状态,60名健康体检者发生焦虑或抑郁状态为15例;治疗总有效率综合组为81．08％,常规组为58．33％。结论头痛患者存在明显焦虑、抑郁的心理异常,加用氟哌噻吨-美利曲辛可明显提高头痛治疗的有效率。

AIM To discuss the relationship between psyche-disorder and headache onset as well as to observe the effection of flupentixol-melitracen in treating headache with depression or anxiety. METHODS Eighty-two headache patients and sixty healthy volunteers were test by self-rating anxiety scale (SAS) and Hamyton depressing scale (HAMD). The incidence of anxiety and depression were compared between 2 groups; 73 cases of headache patients with high score of SAS and HAMD. They were divided randomly into routine treatment group (only anti-headache drugs be used) and the colligation treatment group (anti-headache drugs plus flupentixol-melitracen be used). Headache symptom before and after treatments (in 2 wk and 4 wk) were compared between 2 groups. RESULTS The incidence of anxiety and depression in headache group was higher significantly than that in the healthy control. The effective rate in the colligation treatment group(81.08%) was higher significantly than that in the routine treatment group(58.33%). CONCLUSION The anxiety and depression might be one of the most important factors on patients with headache. flupentixol-melitracen can improve the effective rate of treatment to the headache patients with anxiety and depression.