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目的:观察微粒化非诺贝特对2型糖尿病患者高脂血症的治疗作用.方法:采用自身对照的方法,21例入选病例用微粒化非诺贝特200mg qn,连续服用8wk,治疗期间降糖药物不变.结果:微粒比非诺贝特治疗4wk,就可见TC降低14.7%,TG降低35.8%,TC/HDL-C降低18.5%;8wk时更为明显,分别降低22%、44.9%和27%(P
AIM:To study the effect of micronized fenofibrate in the treatment of hyper-lipidemia in type 2 diabetes mellitus patients. METHODS:Twenty-one patients of type 2 dia-betes mellitus with hyperlipidemia were given micronized fenofibrate 200 mg orally per night for 8 wk without any change in hypoglycemic therapy. RESULTS :TC ,TG and TC/HDL-C decreased by 14. 7%,35. 8%and 18. 5% after 4 wk and by 22%,44. 9% and 27% after 8 wk of micronized fenofibrate administration,respectively (P<0. 01). No difference statistically, LDL decreased from (3.28 ± 1.63) to (2. 78 ± 1.02) mmol/L after 8 wk while no influence on HDL-C, ApoA1 or ApoB was seen after 8 wk of treatment. No adverse reactions was no-ticeable in the 8 wk of observation. CONCLUSION: Micronized fenofibrate is effective and safe in treatment of hyperlipidemia.
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基本信息:
DOI：10.19577/j.cnki.issn10074406.1999.03.003
中图分类号:R587.2
引用信息:
[1]陆怡,程梅芬,吴琳琳.微粒化非诺贝特治疗2型糖尿病患者高脂血症[J].中国临床药学杂志,1999(03):138-140.DOI:10.19577/j.cnki.issn10074406.1999.03.003.
1999-06-15
1999-06-15