中国临床药学杂志

目的评价美罗培南与亚胺培南-西司他丁钠治疗老年重度医院获得性肺炎的有效性和安全性。方法回顾分析132例老年重度医院获得性肺炎使用美罗培南53例或亚胺培南-西司他丁钠79例治疗的临床疗效、细菌清除率、安全性和临床分离菌体外药敏试验。结果美罗培南与亚胺培南-西司他丁钠治疗老年重度医院获得性肺炎的总有效率分别为94.3%(50/53)和88.6%(70/79),痊愈率为88.6%(47/53)和75.9%(60/79)。治疗前共分离细菌123株,美罗培南与亚胺培南-西司他丁钠对细菌的总敏感率分别为95.9%(118/123)和93.5%(87/93),细菌清除率分别为92.3%(48/52)和90.1%(64/71)。药物不良反应发生率分别为9.4%(5/53)和12.6%(10/79),一过性反应较轻。上述2组结果经统计学处理,P均>0.05。结论美罗培南和亚胺培南-西司他丁钠治疗老年重度医院获得性肺炎疗效确切且安全。

AIM To evaluate the efficacy and safety of meropenem and imipenem in the treatment of elderly patients with severe hospital-acquired pneumonia. METHEDS One hundred and thirty-two elderly patients with severe hospital-acquired pneumonia treated with meropenem and imipenem were enrolled in the study retrospectively. RESULTS(A total) of 132 patients were evaluated in this study, 53 patients were in meropenem group, 79 patients in imipenem group. The effective rates of meropenem and imipenem were 94.3% and 88.6%, respectively. The bacterial eradication rates of the 2 groups were 92.3% and 90.1%, respectively.The occurrence rates of the adverse drug reactions were (9.4%) and 12.6% in the 2 groups respectively. There was no statistical significance above figures between the 2 groups. CONCLUSION Meropenem and imipenem is effective and well-tolerated in treatment of elderly severe hospital-acquired pneumonia.