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免疫检查点抑制剂(ICIs)治疗恶性肿瘤过程中出现的免疫相关甲状腺功能障碍(irTD)是由于机体免疫平衡被打破,导致原本稳定的甲状腺功能出现异常。irTD的发生不仅可能影响肿瘤的治疗效果,还可能对患者生存质量乃至生命安全造成威胁。通过对国内外使用ICIs期间发生irTD的相关研究进展进行综述,为临床在使用ICIs期间有效预防或减少irTD的发生提供参考,改善肿瘤患者的预后和生存质量。
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基本信息:
DOI:10.19577/j.1007-4406.2024.01.013
中图分类号:R730.51
引用信息:
[1]时贺敏,殷炜铭,范炜斌.肿瘤免疫治疗中免疫相关甲状腺不良事件的早期危险因素研究进展[J].中国临床药学杂志,2024,33(01):72-76.DOI:10.19577/j.1007-4406.2024.01.013.
基金信息:
浙江省医药卫生科技计划项目(编号2024KY428); 白求恩·肿瘤基础研究计划项目(编号BCF-XD-JC-20221205-06); 浙江省药学会药品临床综合评价专项科研资助项目(编号2022ZYYL16)
2024-01-25
2024-01-25