| 365 | 2 | 64 |
| 下载次数 | 被引频次 | 阅读次数 |
目的探讨抗感染治疗中多药联用后药物不良反应的药学监护。方法临床药师利用药学知识结合临床,对患者及疾病情况开展药学监护。结果美罗培南诱发患者发生癫痫;头孢哌酮舒巴坦联合环磷腺苷葡胺及多索茶碱致患者血小板下降。结论抗感染药物治疗时应加强对药物不良反应的监护,特别注重多药联用时药物相互作用。
Abstract：[1]PERROS M.Infectious disease.A sustainable model for antibiotics[J].Science,2015,347(6226):1062.
[2]肖永红,侯芳,王进,等.抗菌药物不良反应的社会与经济后果调查[J].中国卫生经济,2010,29(5):94.
[3]CHOW KM,HUI AC,SZETO CC.Neurotoxicity induced by betalactam antibiotics:from bench to bedside[J].Eur J Clin Microbiol Infect Dis,2005,24(10):649.
[4]SUNAGAWA M,MATSUMURA H,SUMITA Y,et al.Structural features resulting in convulsive activity of carbapenem compounds:effect of C-2 side chain[J].J Antibiot(Tokyo),1995,48(5):408.
[5]CANNON JP,LEE TA,CLARK NM,et al.The risk of seizures among the carbapenems:a meta-analysis[J].J Antimicrob Chemother,2014,69(8):2043.
[6]BARABOUTIS I G,MARANGOS MN,SKOUTELIS A,et al.Meropenem-aggravated seizure activity in progressive myoclonus epilepsy[J].Int J Antimicrobial Agents,2008,31(2):177.
[7]MILLER AD,BALL AM,BOOKSTAVER PB,et al.Epileptogenic potential of carbapenem agents:mechanism of action,seizure rates,and clinical considerations[J].Pharmacotherapy,2011,31(4):408.
[8]朱爱华,时晶,倪敬年,等.头孢哌酮钠/舒巴坦钠致凝血功能异常[J].药物不良反应杂志,2011,13(6):373.
[9]ALAGOZLU H,CINDORUK M,UNAL S.Severe INR elevation in a patient with choledocholithiasis receiving cefoperazone[J].Clin Drug Investig,2006,26(8):481.
[10]吴斌,戴晓琴,张春红,等.头孢哌酮/舒巴坦钠对凝血功能的影响及处理[J].中国急救医学,2013,33(3):228.
[11]吴大玮,赵颖,杨艳萍,等.环磷腺苷-葡甲胺治疗慢性肺心病心肺功能不全多中心临床研究[J].中华内科杂志,2001,40(7):467.
基本信息:
DOI：10.19577/j.cnki.issn10074406.2017.04.015
中图分类号:R969.3
引用信息:
[1]王彧杰,张杰,王欢,等.抗感染治疗过程中药物不良反应的药学监护[J].中国临床药学杂志,2017,26(04):272-274.DOI:10.19577/j.cnki.issn10074406.2017.04.015.
基金信息:
上海市药学会基金(编号2015-YY-01-11)
2016-07-21
2016
2017-01-23
2017-06-13
2017
1
2017-07-25
2017-07-25