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目的评价国产与进口氟西汀的临床疗效、安全性。方法将选择本院门诊、住院抑郁症患者60例,随机分为国产氟西汀组30例和进口氟西汀组30例,分别口服国产及进口氟西汀20mg·d-1,疗程6wk。结果国产组痊愈率为70%,有效率为86·6%,进口组痊愈率为66·7%,有效率90%,2组疗效差异无统计学意义(P>0.05)。国产组和进口组不良反应发生率分别是26·6%和23·3%,2组的不良反应轻微。常见不良反应有:失眠和焦虑、头痛、厌食等。结论国产与进口氟西汀的抗抑郁作用疗效相当。
Abstract：AIM To evaluate the efficacy and safety of domestic and imported fluoxetine in the treatment of depression.METHODS Sixty patients with depression were divided into domestic group〔M 14,F 16,age (42.3±12.7)a〕and imported group 〔M 15,F 15,age (43.3±13.7)a〕by a randomized,controlled group design.The domestic and imported group were treated with domestic and the imported fluoxetine 20 mg·d -1 for 6 wk respectively.RESULTS The cure rates and effective rates of domestic and imported group were 70% and 86.6%,66.7% and 90% respectively ( P>0.05).No severe adverse drug reactions were found.The adverse drug reactions rates in the domestic and imported were 26.6% and 23.3% respectively.The frequent adverse drug reactions were insomnia,anxiety,headache and nausea.There was no significant difference between 2 groups (P>0.05).CONCLUSION Domestic fluoxetine is as effective and safe as imported one in treatment of depression,the tolerance and compliance are good.
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基本信息:
DOI：10.19577/j.cnki.issn10074406.2006.05.013
中图分类号:R749.4
引用信息:
[1]王来海,李梅香,王长虹,等.国产与进口氟西汀治疗抑郁症的疗效比较[J].中国临床药学杂志,2006(05):307-309.DOI:10.19577/j.cnki.issn10074406.2006.05.013.
2006-09-25
2006-09-25