中国临床药学杂志

目的 :比较克拉霉素和多西环素治疗非淋菌性宫颈、尿道炎的疗效。方法 :92例患者分为 2组 ,治疗组 (n =5 0 )用克拉霉素 5 0 0mg ,po ,bid ,疗程 10d ;对照组 (n =4 2 )用多西环素 2 0 0mg,po ,bid ,疗程 14d。并对 2组治疗的有效率和病原体清除率进行比较。结果 :治疗组与对照组有效率分别为 82 %及 71 4 % ,痊愈率分别为 74 %及 5 2 4 % ,2组相比 ,差异有显著性 (P <0 0 5 )。结论 :克拉霉素对女性非淋菌性宫颈、尿道炎的临床疗效优于多西环素。

AIM: To compare the efficacy between doxycycline and clarithromycin in the treatment of non gonococcal genito urethritis. METHODS: The study was conducted in 92 patients with non gonococcal genito urethritis, which were randomly divided to receive clarithromycin in dose of 500 mg, po , bid, were treated for 10 d, or doxycycline in dose of 200 mg, po , bid, were treated for 14 d. RESULTS: The total effective rate, cure rate for clarithromycin were 82%, 74%; for doxycycline were 71 4%, 52 4%. There was significant difference between active and control groups ( P <0 05). CONCLUSION: Clarithromycin is an effective and safe drug for treatment of non gonococcal genito urethritis.