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目的:建立霉酚酸酯(MMF)与环孢素A(CsA)及皮质激素(Pred)合用时CsA的治疗窗,分析霉酚酸酯在肾移植术后的临床疗效.方法:对临床164份病例资料进行回顾性分析.结呆:MMF方案CsA的治疗窗为:1mo内为150～300ng/ml,1～3mo 120～260ng/ml,3～6mo 110～225ng/ml;MMF方案中毒反应、排异反应发生均低于经典三联方案(CsA+硫唑嘌呤Aza+Pred).结论:MMF方案优于经典三联方案,可安全、有效地预防肾移植术后急慢性排斥及中毒反应的发生率.
Abstract：AIM: To establish the optimal therapeutic window of cyclosporine A (CsA) for mycophenolate mofetil (MMF) combined with cyclosporine A and prednisone acetate,and analyse clinical effects on patients in renal transplantation. METHODS :One hundred and six-ty-four clinical medical records were summarized with retrospective analysis. RESULTS: The optimal therapeutic window of CsA with MMF was 150-300 ng/ml(less than 1 mo after op-eration), 120-260 ng/ml (1 mo-<3 mo), 110-225 ng/ml (3 mo-<6 mo); The rate of rejection and toxic incidence of MMF group was less than old triple therapy with CsA, aza-thioprine and steroids. CONCLUSION: The MMF combined with cyclosporine and steroids is more effective than control group.
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基本信息:
DOI：10.19577/j.cnki.issn10074406.1999.s1.005
中图分类号:R699.2
引用信息:
[1]董亚琳,王镭,田普训.霉酚酸酯在肾移植术后的临床应用[J].中国临床药学杂志,1999(S1):10-13.DOI:10.19577/j.cnki.issn10074406.1999.s1.005.
1999-12-30
1999-12-30