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目的 :考察不同厂家双氯芬酸钠 ( DS)缓释制剂的含量及溶出度 ,评价其内在质量。方法 :紫外分光光度法测定含量及溶出度 ,检测波长 :2 76 nm。结果 :不同厂家的 DS缓释制剂的体外溶出度有显著性差异。结论 :为了确保 DS缓释制剂的临床疗效 ,应对其进行体外溶出度的测定
Abstract：AIM:To determine content and dissolution of diclofenac sodium sustained release medication. METHODS: The content and dissolution were determined by UV at 276 nm. RESULTS: There were significant differences in dissolution between the products from different factories. CONCLUSION: It is necessary to control the dissolution of diclofenac sodium sustained release medication before clinical use.
[ 1]陈新谦 .新编药物学 (第 14版 ) .北京 :北京人民卫生出版社 ,1997,15 8
[2 ]李洪奎 ,李常春 ,李蜀魏 ,等 .双氯芬酸钠缓释片人体体内外相关性研究 .中国药房 ,1997,8(5 ) :2 0 3
[3]于西全 ,左晖 ,康鲁平 ,等 .复方双氯灭痛微胶囊的制备及溶出度研究 .中国医院药学杂志 ,1998,18(2 ) :6 5
基本信息:
DOI：10.19577/j.cnki.issn10074406.2001.02.014
中图分类号:R927.2
引用信息:
[1]毛静怡,蒋东.双氯芬酸钠缓释制剂含量及体外溶出度的测定[J].中国临床药学杂志,2001(02):105-106.DOI:10.19577/j.cnki.issn10074406.2001.02.014.
2001-04-25
2001-04-25