2005 05 291-294
中药枳实对功能性消化不良大鼠胃排空的影响
基金项目(Foundation):
邮箱(Email):
DOI:
10.19577/j.cnki.issn10074406.2005.05.009
中文作者单位:
南京军区福州总医院消化内科,南京军区福州总医院消化内科,南京军区福州总医院消化内科 福州350025 ,福州350025 ,福州350025
摘要(Abstract):
目的研究枳实对功能性消化不良大鼠胃排空的影响及其可能机制。方法健康成年Wistar大鼠30只,随机分为正常对照组、模型组和模型+枳实组。测定各组大鼠胃排空速率,并对大鼠胃窦组织进行P物质、胃动素及血管活性肠肽免疫组化染色。结果模型组大鼠胃排空速率明显低于正常对照组(P<0.01)。应用枳实水提取液后大鼠胃排空速率增加,与正常对照组无明显差异(P>0.05)。模型组大鼠胃窦组织P物质、胃动素明显低于正常对照组(P<0.01或P<0.05),血管活性肠肽明显高于正常对照组(P<0.05)。应用枳实水提取液后大鼠胃窦组织P物质、胃动素明显增加,血管活性肠肽明显减少,与正常对照组无明显差异(P>0.05)。结论枳实可改善功能性消化不良大鼠的胃排空,其机制可能与胃窦组织P物质、胃动素的分布增加及血管活性肠肽的减少有关。
关键词(KeyWords):
枳实;;P物质;;血管活性肠肽;;胃动素
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参考文献
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[6]Maake C,Kloas W,Szendefim,et al.Neurohormonal peptides,sero-tonin and nitric oxide synthase in the enteric nervous system and en-docrine cells of the gastrointestinal tract of neotenic and thyroid hormone-treated axolotls[J].Cell Tissue Res,1999,297(1):90.
[7]Lordal M,Theodorsson E,Hellstrom PM.Tachykinms influence interdi-gestive rhythm and contractive strength of human small intestine[J].DigDis Sci,1997,42(9):1940.
[8]Wheatley IM,Hutson JM,Chow CW,et al.Slow-transit constipation inchildhood[J].J Pediatr Surg,1999,34(5):829.
[9]Sasaki W,Yoshihara T.The effect of motilin on the regulation mecha-nism of intestinal motility in conscious horses[J].J Vet Med Sci,1999,61(2):167.
[10]Ljung T,Hellstrom PM.Vasoactive intestive peptide suppress migrat-ing myoelectric complex of rat small intestinal indepent of nitric oxide[J].Acta Physiol Scand,1999,165(2):225.
[11]Li LS,Qu RY,Wang W,et al.Significance of changes of gastroin-testinal peptides in blood and ileum of experimental spleen deficiencyrats[J].World J Gastroenterol,2003,9(3):553.
[12]Sandgren,K,Lin Z,Svenningsen AF,et al.Vasoactive intestinalpeptide and nitric oxide promote survival of adult rat myenteric neuronsin culture[J].J Neurosci Res,2003,72(5):595.
基本信息:
DOI：10.19577/j.cnki.issn10074406.2005.05.009
中图分类号:R285;
引用信息:
[1]朱金照,张志坚,张捷.中药枳实对功能性消化不良大鼠胃排空的影响[J].中国临床药学杂志,2005(05):291-294.DOI:10.19577/j.cnki.issn10074406.2005.05.009.
基金信息: