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目的寻找医嘱中药物联用致不良反应的理论预测与实际发生情况之间差异的规律。方法利用"e药通"软件分析上海市第一人民医院神经外科一季度住院患者医嘱,得出理论预测数据;查看患者电子病历系统用药前后肌酐、钾离子、凝血酶原时间、血糖等结果的变化趋势,分析药物相互作用对患者病情的实际影响,从而得出差异规律。结果分析2 109次223种药物相互作用,其中肾功能损伤的85条中实际发生48条;影响钾离子的76条中发生14条;改变凝血功能的24条中发生5条;7条血糖影响未知。药物相互作用的临床实际发生率为34.9%,实际发生的病例中以肾功能损害,特别是降压药物与抗菌药物联用致肾功能损害为多见。结论利用软件分析药物相互作用时需与临床实践相结合,对药物不良反应实际发生率较高的药物进行定期总结和加强监护。
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基本信息:
DOI：10.19577/j.cnki.issn10074406.2017.02.014
中图分类号:R95
引用信息:
[1]梁悦,赵彤,高岸,等.神经外科常用药物联用致不良反应的理论预测与临床实践差异的规律分析[J].中国临床药学杂志,2017,26(02):130-132.DOI:10.19577/j.cnki.issn10074406.2017.02.014.
基金信息:
上海市卫计委优秀青年人才培养计划(编号XYQ2013091)
2016-01-22
2016
2017-01-10
2017
2016-12-30
1
2017-03-25
2017-03-25