中国临床药学杂志

目的观察草酸艾司西酞普兰治疗老年冠心病并发抑郁症患者的疗效。方法选择冠心病伴发抑郁障碍患者54例,随机分为治疗组(30例)与对照组(24例)。治疗组给予草酸艾司西酞普兰治疗和心理干预,起始日剂量10 mg,最高日剂量为20 mg,并行积极心理干预,总疗程为6周;对照组采用常规药物治疗。治疗1、2、4、6周后评定疗效,同时观察不良反应。结果治疗组患者治疗1、2、4、6周后SAS、SDS、HAMD评分、抑郁情绪改善程度和血清同型半胱氨酸、超敏C反应蛋白下降程度、临床总有效率均优于对照组(P<0.01或P<0.05)。结论草酸艾司西酞普兰治疗加上心理干预对冠心病抑郁症患者疗效好,且起效快(1周),依从性好,不良反应少,安全性高。

AIM To observe and analyze the clinical effect of escitalopram oxalate on depression complicated by coronary heart disease in elderly patients. METHODS A total of 54 cases accompanied with depression were divided into 2 groups randomly: the treatment group( n = 30) and the control group( n = 24). The treatment group was given escitalopram oxalate at an initial dose of 10 mg( not more than 20 mg) a day and positive psychological intervention. The total period of treatment was 6 weeks. The control group was given conventional medical treatment.The effects were evaluated after 1,2,4,6 weeks,and adverse drug reactions were observed. RESULTS After treating for 1,2,4,6 weeks,scores of SAS,SDS,HAMD,the situation of improved depression,the degree of decrease with homocysteine,hypersensitive C-reactive protein and clinical total efficiency of the treatment group were better than those of the control group( P < 0. 01 or P < 0. 05). CONCLUSION Escitalopram oxalate is effective and safe in the treatment of depression complicated by coronary heart disease,and has the characteristics of faster onset of action( after 1 week),better compliance and fewer adverse drug reactions.