中国临床药学杂志

目的 :研究青娥丸对骨质疏松症 (OP)动物模型的骨代谢调节作用与作用机制。方法 :8只大鼠行假手术作为对照组 ;2 4只大鼠行去势法制作OP动物模型后分为OP组、雌二醇组和青娥丸组。检测血钙 (Ca)、血磷 (P)、血雌激素 (E)、碱性磷酸酶(ALP)、耐酒石酸盐酸性磷酸酶 (TRAP)和骨密度 (BMD)等指标。结果 :上述各项指标 ,青娥丸组与OP组的比较有显著性差异(P <0 0 5～ 0 0 1)。结论 :青娥丸治疗OP模型动物的骨质疏松效果显著

AIM: To study the adjusting effect of Qing-er pill on bone metabolism in osteoporosis (OP) model animals' OP and its mechanism. METHODS: Eight rats that had been done sham-ovariectomy were made control group, 24 rats that had been done ovariectomy were made OP group, estradiol group and Qing-er pill group respectively. Biochemical indexes of bone metabolism were tested. These indexes included blood calcium (Ca); blood phosphor (P); blood estrogen (E); alkaline phosphatase (ALP); tartrate-resistant acid phosphatase (TRAP) and bone mineral density (BMD). RESULTS: It was different significantly when Qing-er pill group campared with OP group of these biochemical indexes (P<0.05 - P<0.01). CONCLUSION: Qing-er pill can be used for treatment of osteoporosis of OP model animal effectively.