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卢美哌隆为一种首创(First-in-Class)新药,于2019年12月23日获FDA批准上市,用于治疗成人精神分裂症。作为一种新型非典型抗精神病药物,卢美哌隆能够对5-羟色胺(5-HT)、多巴胺(DA)和谷氨酸神经递质通路同时进行调节,是5-HT2A受体拮抗剂、也是5-HT再摄取抑制剂;是DA受体磷酸蛋白调节剂(DPPM),也是突触前D2受体的部分激动剂和突触后D2受体的拮抗剂;而且还能间接调节谷氨酸受体活性。该药安全、有效,锥体外系不良反应(EPS)少,代谢异常和体质量增加的发生率较低,具有良好的耐受性。通过综述该药临床疗效和不良反应,为临床用药和后续的临床试验提供参考。
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基本信息:
DOI:10.19577/j.1007-4406.2021.05.017
中图分类号:R971
引用信息:
[1]盛钦润,沈一峰,李华芳.新型抗精神病药:卢美哌隆[J].中国临床药学杂志,2021,30(05):389-395.DOI:10.19577/j.1007-4406.2021.05.017.
基金信息:
上海市精神心理疾病临床医学研究中心(编号19MC1911100); 上海交通大学医学院转化医学协同创新中心—精神药物临床试验平台建设(编号TM202016)
2021-09-25
2021-09-25