中国临床药学杂志

目的通过药物利用评价(DUE)方法评价某院比阿培南临床应用情况,为促进临床合理使用比阿培南提供参考。方法随机抽取2015年7月至2017年6月使用比阿培南的187例病历,依据建立的DUE标准进行回顾性分析。结果 (1)用药指征:适应证符合标准率98. 4%,有禁忌证占5. 3%;(2)用药过程:实验室指标监测符合标准率62. 0%(生命体征、病原学、全血和白细胞、肝肾功能监测符合率标准分别为100%、80. 7%、82. 4%、82. 9%),有用药相互作用的占4. 3%,用法用量、溶媒、特殊人群、疗程和联合用药符合标准率100%;(3)用药结果:治疗有效率85. 6%,不良反应监测符合标准率95. 2%;(4)管理指标:病程记录符合标准占95. 7%,会诊、处方权符合率100%。结论比阿培南的临床使用存在一定问题和不足,建立比阿培南DUE标准可用于规范比阿培南的临床使用。

AIM To evaluate the clinical utilization of biapenem in a hospital with drug use evaluation( DUE),and provide reference for rational use of biapenem. METHODS On a basis of biapenem DUE criteria,a retrospective analysis was made in 187 hospitalized patients with biapenem in the hospital from July 2015 to June2017. RESULTS(1)Medication indication: the coincidence rate of medication indication was 98. 4%,and contraindication rate was 5. 3%;(2) Medication process: laboratory indicators rate was 62. 0%( the coincidence rate of vital signs was 100%,etiological examination was 80. 7%,blood monitoring was 82. 4%,liver and kidney function monitoring was 82. 9%),the drug interaction rate was 4. 3%,the medication usage and dosage,solvent selection,special crowd,course of treatment and drug combination rate were 100%;(3)Medication results: the treatment effective rate was 85. 6% and adverse drug reaction monitoring rate was 95. 2%;(4)Management indicators:the coincidence rate of progress notes was 95. 7% and consultation,prescribing authority was 100%. CONCLUSION There are some inappropriate medication problems in biapenem utilization in the hospital. Established DUE criteria possesses of biapenem can standardize the clinical utilization of biapenem.