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利特昔替尼是一种特异性Janus激酶(JAK)3共价抑制剂,通过阻断导致斑秃的信号分子传导,抑制免疫细胞因子的活性,阻止免疫系统杀伤毛囊细胞,进而发挥治疗作用。美国FDA于2023年批准利特昔替尼用于12岁及以上患者重度斑秃的治疗。利特昔替尼作为首款获批的治疗青少年严重斑秃的靶向药,临床疗效显著,并且安全性和耐受性良好,常见的不良反应为头痛、腹泻、痤疮和皮疹等。
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基本信息:
DOI:10.19577/j.1007-4406.2024.09.010
中图分类号:R986
引用信息:
[1]张亚安,朱咏娟,林玉婷,等.新型青少年斑秃治疗药物:选择性JAK3/TEC抑制剂利特昔替尼[J].中国临床药学杂志,2024,33(09):692-696.DOI:10.19577/j.1007-4406.2024.09.010.
基金信息:
江苏省高等学校大学生实践创新训练计划项目(编号HCX23013,YXQ2024004); 江苏省青蓝工程优秀青年骨干教师培养资助(编号2023); 江苏高校哲学社会科学研究一般项目(编号2023SJYB0659); 东南大学成贤学院国家级科研项目培育基金(编号2022NCF001)
2024-09-25
2024-09-25