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目的 观察L-阿拉伯糖联合二甲双胍对新诊断2型糖尿病（T2DM）患者胰岛β细胞功能的影响。方法 选取2019年1月至2020年6月在内分泌代谢科门诊就诊的新诊断为T2DM的患者53例，按照随机数字表法分为对照组和观察组，对照组27例，观察组26例。对照组为单用二甲双胍，观察组为二甲双胍联合L-阿拉伯糖，比较2组胰岛β细胞功能等方面的差异。结果 治疗12周时，2组患者血糖、糖化血红蛋白（Hb A1c）、空腹胰岛素（FINS）和空腹C肽均较治疗前下降（P <0.01）；观察组胰岛β细胞功能指数（HOMA-β）较治疗前升高（P <0.01）；观察组血糖、Hb A1c、空腹胰岛素（FINS）和胰岛素抵抗指数（HOMA-IR）均低于对照组（P <0.05），经HOMA-IR校正后的胰岛β细胞功能指数（HBCI/IR）和空腹β细胞功能指数（FBCI/IR）、胰岛素敏感指数（ISI）均高于对照组（P <0.01）；观察组餐后2 h胰岛素（2h INS）、餐后2 h C肽、HBCI/IR、FBCI/IR、ISI均较对照组显著改善（P <0.05）。结论 L-阿拉伯糖与二甲双胍联合应用对降低血糖、餐后胰岛素峰值以及改善胰岛β细胞分泌功能均优于单用二甲双胍。
Abstract：AIM To investigate the effects of L-arabinose combined with metformin on pancreatic β cell function in patients newly diagnosed with type 2 diabetes mellitus(T2DM). METHODS Newly diagnosed T2DM 53 patients admitted to department of endocrinology from January 2019 to June 2020 were randomly divided into control group(n = 27) treated with metformin and observation group(n = 26) treated with metformin combined with L-arabinose. Then the pancreatic β cell function were compared between 2 groups. RESULTS At week 12 of treatment, significant decline was noticed in the term of blood glucose, glycosylated hemoglobin(HbA1c), fasting insulin(FINS), and fasting C-peptide(P < 0.01) in control group and observation group compared with baseline level. The homeostasis model assessment insulin resistance index of islet β cells(HOMA-β) in the observation group showed significant elevation compared with the baseline level(P < 0.01). Compared with the control group, significant decline was noticed in blood glucose, HbA1c and FINS as well as HOMA-IR in the observation group(P < 0.05). After adjusting with HOMA-IR in the observation group, there was significant elevation in the HBCI/IR, FBCI/IR and insulin sensitive index(ISI) compared with the control group(P < 0.01). There was significant improvement in observation group in the changes of 2hINS, postprandial 2 h C peptide, HBCI/IR, FBCI/IR and ISI compared with control group(P < 0.05). CONCLUSION The combination of L-arabinose and metformin is superior to metformin in reducing blood glucose, peak value of postprandial insulin and improving the secretion function of islet β cells.
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基本信息:
DOI：10.19577/j.1007-4406.2023.05.009
中图分类号:R587.1
引用信息:
[1]陈叶红,斯徐伟,诸葛福媛,等.L-阿拉伯糖联合二甲双胍对新诊断2型糖尿病患者胰岛β细胞功能的影响[J].中国临床药学杂志,2023,32(05):368-372.DOI:10.19577/j.1007-4406.2023.05.009.
基金信息:
浙江省绍兴市科技计划（医卫类）项目（编号2018C30106）
2023-05-25
2023-05-25