中国临床药学杂志

目的 :以氨甲蝶呤 (MTX)为对照 ,观察米非司酮 (Mif)治疗异位妊娠的效果。方法 :将 5 8例患者随机分为米非司酮组和氨甲蝶呤组进行比较。结果 :2组均于治疗后 8d血人绒毛膜促性腺激素开始明显下降 ,与治疗前比较差异显著 ,治疗后 15 d包块平均直径缩小 5 0 % ,差异显著 (P<0 .0 5 )。 2组治疗成功率均在 80 %以上。结论 :两种药物治疗异位妊娠有同样效果 ,但MTX有一定的不良反应 ,而 Mif无一例发生不良反应 ,且给药方便 ,可作为异位妊娠保守治疗的药物之一

AIM: To study the response of ectopcic pregnancy to mifepristone compared with methorexate. METHODS: Fifty eight cases were divided into group A and B by random. Group A was treated with mifepristone, group B with methorexate. RESULTS: The serum β hCG of 2 groups was declined remarkably after 8 d of treatment ( P <0 05), mass diameter decreasing was 50% after 15 d of treatment ( P <0 05). Cure rate of 2 groups was 80% above. CONCLUSION: There are same effects with 2 drugs in treating ectopic pregnancy, but there is adverse drug reaction with methorexate. There is not adverse drug reaction with mifeprestone, and it can be conveniently used as ideal drug in treating ectopic pregnancy, especially to those who need to keep reproductive function.