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一例心脏瓣膜置换术后抗凝治疗患者因上消化道出血入院,给予调整华法林剂量抗凝治疗,期间患者多次出现出血和国际标准化比值(INR)波动。临床药师从疾病及药物相互作用等多方面因素进行分析,同时结合药动学和药效学特点,向临床提供合理建议,对患者进行用药指导,保障患者用药安全。
Abstract：[1]付博,董力,石应康.中国人心脏瓣膜置换术后抗凝治疗数据库建设[J].中国胸心血管外科临床杂志,2013,20(1):3.
[2]Yuan HY,chen JJ,Lee MT,et al.A novel functional VKORCl promoter polymorphism is associated with inter-individual and inter-ethnic differences in warfar in sensitivity[J].Hum Mol Genet,2005,14(13):1745.
[3]Lam MP,cheung BM.The phamacogenetics of the response to warfarin in chinese[J].Br J Clin Pharmacol,2011,73(3):340.
[4]Whitlock RP,Sun JC,Fremes SE,et al.Antithrombotic and thrombolytic therapy for valvular disease:Antithrombotic Therapy and Prevention of Thrombosis,9th ed:American College of Chest Physicians Evidence-Based Clinical Practice Guidelines[J].Chest,2012,141(2):e576S.
[5]刘媛,余细勇,钟诗龙,等.心脏瓣膜置换术后华法林抗凝治疗的单中心临床应用调查[J].南方医科大学学报,2010,30(10):2242.
[6]王志伟,徐明星,计乐群.心脏瓣膜置换术后低强度抗凝研究[J].中华实验外科杂志,2005,22(4):484.
[7]马俊珩,葛卫红,于锋.心脏瓣膜置换术后华法林低强度抗凝的疗效观察[J].吉林医学,2012,33(31):6759.
[8]Ricder MJ,Riener AP,Gage BF,et al.Effect of VKORCI haplotypes on transcriptional regulation and warfarin dose[J].N Engl J Med,2005,352(22):2258.
[9]Kellett HA,Sawers JS,Boulton FE,et al.Problems of anticoagulation with warfarin in hyperthyroidism[J].Q J Med,1986,58(225):43.
[10]顾寅明,魏萌,宋莎莎,等.阿奇霉素对大鼠灌服华法林的药效学和药动学的影响[J].药学进展,2010,34(3):125.
[11]Yu HCM,Chan TYK,Critchley JAJH,et al,Factors determining the maintenance dose of warfarin in Chinese patients[J].Q J Med,1996,89(2):127.
[12]姜敏,熊玉卿.细胞色素氧化酶P4503A4与药物代谢[J].实用临床医学,2006,7(11):199.
[13]方冀,刘洋.抗菌药物与口服抗凝血药的相互作用[J].药物与临床,2001,16(2):19.
基本信息:
DOI：10.19577/j.cnki.issn10074406.2014.05.016
中图分类号:R654.2
引用信息:
[1]胡文娟,王欢,黄瑾.心脏瓣膜置换术后抗凝治疗出血的药学监护[J].中国临床药学杂志,2014,23(05):325-328.DOI:10.19577/j.cnki.issn10074406.2014.05.016.
基金信息:
浦东新区卫生和计划生育委员会卫生科技项目(编号PW2014B-18)
2014-09-25
2014-09-25