中国临床药学杂志

目的 :观察冬虫夏草对离体人肾小球系膜增殖的疗效 ,并探讨其机制。方法 :利用体外培养的人肾小球系膜细胞 ,采用检测 3H胸腺嘧啶掺入量的方法 ,研究北冬虫夏草和天然冬虫夏草对低密度脂蛋白 (L DL )引起系膜细胞增殖的影响。结果 :2组冬虫夏草组的 3H掺入率均明显低于 L DL对照组 (P<0 .0 1) ,而 2组冬虫夏草之间同一浓度相比无显著性差异 (P>0 .0 5 )。结论 :冬虫夏草明显抑制 L DL引起的系膜细胞增殖 ,北冬虫夏草与天然冬虫夏草作用相似。其机制可能是由于冬虫夏草间接抑制了系膜细胞增殖过程中 DNA的合成。

AIM: To assess the effect of cordyceps on human mesangial cells (HMCs) that cultured in vitro, and discuss the underlying mechanism. METHODS: The effects of cordyceps militaris and condyceps sinensis on the proliferation of cultured HMCs caused by low density lipoprotein (LDL) were evaluated by 3H thymidine incorporation. RESULTS: The value of count per minute (cpm) in both cordyceps groups was significantly lower than LDL control group ( P <0 01). While applying the same concentration of medicine, there was no significant difference between 2 cordyceps groups ( P >0 05). CONCLUSION: Corydceps strongly inhibits the proliferation of cultured HMCs. Cordyceps militaris has a similar effect as cordyceps sinensis . The effect is possibly due to the indirect inhibition of DNA synthesis of HMCs by Cordyceps 。