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14例有较长病史的癫痫患者(6例为GTC发作,7例为CP发作,1例为GTC合并CP发作)及2例新发病的GTC发作患者,服用卡马西平缓释片进行疗效观察,结果8例获完全控制,4例发作次数明显减少,4例无效。卡马西平缓释片的血浓波动指数为22.85％,明显低于普通片(42.32％,P<0.05)。
Abstract：14 patients with chronic course of epilepsy (6 with GTC seizure, 7 with cp seizure, 1 with both GTC and CP seizure) and 2 new patients were treated with sustained release carbamazepine tablet (SR-CBZ). 8 had no seizure, 4 had a Significat reduction in the number of sailure, 4 had no change. Fluctuation Index (FI)of SR-CBZ (22. 58%)was significantly less than that of conventional carbamazebine tablet (C-CBZ) (42.32%) P<0. 05.
1 Eichelbaum M,Ekbom K,Bertilson L,et al. Plasma Kinetics of carbamazepine and its epoxide metabolite in man after single and multiple doses. Eur J clin pharmacol 1975; 8:337
2 Tomson T. Interdosage fluctuations in plasma carbamazepine concentration determine intermittent side effects. Arch Neurol 1984; 41: 830
3 瞿治平。癫痫发作分类及药物临床疗效评定的建议(草案)。神经精神疾病杂志 1980;6:248
基本信息:
DOI：10.19577/j.cnki.issn10074406.1995.03.005
中图分类号:R96
引用信息:
[1]余自成,张静华,王宏图,钟明康,张莉莉,俞丽云.卡马西平缓释片疗效的初步观察[J].临床药学,1995(03):13-14+23.DOI:10.19577/j.cnki.issn10074406.1995.03.005.
1995-09-30
1995-09-30