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报道1例XELOX化疗方案致Stevens-Johnson综合征(SJS)的病例。患者女性,58岁,因第4周期使用奥沙利铂(175mg,iv gtt,qd,第1天)联合卡培他滨(1 500 mg,po,bid,第1~14天)化疗后出现全身皮疹2 d伴发热、腹泻入院。入院后被诊断为SJS。通过停用卡培他滨并积极使用糖皮质激素和注射用免疫球蛋白对症支持治疗,12 d后患者皮肤反应逐渐好转。临床药师结合患者的用药史采用Naranjo评估量表进行评分:奥沙利铂3分,有可能导致SJS;卡培他滨计5分,极有可能导致SJS。
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基本信息:
DOI:10.19577/j.1007-4406.2022.09.012
中图分类号:R969.3
引用信息:
[1]郭凯,朱斌,常莹莹.XELOX化疗方案致Stevens-Johnson综合征1例[J].中国临床药学杂志,2022,31(09):701-704.DOI:10.19577/j.1007-4406.2022.09.012.
2022-09-25
2022-09-25