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2020, 02, v.29 152-156
隐丹参酮抗肿瘤活性与逆转化疗耐药作用的研究进展
基金项目(Foundation): 上海市临床药学重点专科建设项目(区属); 静安区医学科研课题(编号2019MS03); 上海市药学会医院药学科研基金(编号2019-Y025); 上海市静安区中心医院国家自然科学种子基金; 国家重点研发计划课题(编号2018YFC2002404)
邮箱(Email):
DOI: 10.19577/j.1007-4406.2020.02.019
摘要:

隐丹参酮(CTS)是从中草药丹参根茎中提取的单体成分,相对分子质量小,可透过血脑屏障,近年来通过体内外各种实验被证实对冠心病、动脉粥样硬化、关节炎、内分泌失衡、脑损伤和阿尔茨海默病等疾病具有药理活性。在抗肿瘤方面不仅可通过抑制细胞增殖、诱导肿瘤细胞凋亡、抑制肿瘤细胞转移侵袭和抗新生血管生成等机制而发挥抗肿瘤作用,同时还具有与部分化疗药物联合,增敏化疗疗效或逆转化疗耐药的作用。通过对CTS在各种肿瘤中的抗肿瘤药理活性与逆转肿瘤耐药进行综述,为其在临床研究中的应用提供参考。

Abstract:

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参考文献

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基本信息:

DOI:10.19577/j.1007-4406.2020.02.019

中图分类号:R285

引用信息:

[1]李光慧,王利苹,赵贝,等.隐丹参酮抗肿瘤活性与逆转化疗耐药作用的研究进展[J].中国临床药学杂志,2020,29(02):152-156.DOI:10.19577/j.1007-4406.2020.02.019.

基金信息:

上海市临床药学重点专科建设项目(区属); 静安区医学科研课题(编号2019MS03); 上海市药学会医院药学科研基金(编号2019-Y025); 上海市静安区中心医院国家自然科学种子基金; 国家重点研发计划课题(编号2018YFC2002404)

发布时间:

2020-03-25

出版时间:

2020-03-25

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