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2012, 06, v.21 392-394
抗肿瘤药物作用的新靶点——CHOP/GADD153凋亡通路
基金项目(Foundation): 国家自然科学基金(编号:30672442、81071887); 山东省自然科学基金(编号:ZR2011HQ05)
邮箱(Email):
DOI: 10.19577/j.cnki.issn10074406.2012.06.019
摘要:

CHOP/GADD153是内质网应激反应特异的转录因子,参与各种细胞活动特别是能量代谢、增殖、分化、凋亡的调节。CHOP在正常情况下表达很低,在内质网应激反应时表达显著升高。CHOP介导的凋亡通路是内质网应激相关凋亡通路中的重要途径。本文综述了CHOP/GADD153介导的细胞凋亡与肿瘤研究的新进展,对于肿瘤的生物治疗具有一定的参考价值。

Abstract:

KeyWords:
参考文献

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基本信息:

DOI:10.19577/j.cnki.issn10074406.2012.06.019

中图分类号:R96

引用信息:

[1]马健,王浩,苏雪慧,等.抗肿瘤药物作用的新靶点——CHOP/GADD153凋亡通路[J].中国临床药学杂志,2012,21(06):392-394.DOI:10.19577/j.cnki.issn10074406.2012.06.019.

基金信息:

国家自然科学基金(编号:30672442、81071887); 山东省自然科学基金(编号:ZR2011HQ05)

发布时间:

2012-11-25

出版时间:

2012-11-25

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