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<正>为了提高药物的治疗指数,Bodor等提出和发展了逆代谢药物设计的概念,它包含2种不同的设计策略:软药(soft drug)和化学药物给药系统。软药设计(soft drug design)是将化合物的构效关系(structure-activity relationship,SAR)与构代关系(structure-metabolism relationship,SMR)以及理化性质相结合,目的是设计出更安全的化合物。
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基本信息:
DOI：10.19577/j.cnki.issn10074406.2004.04.028
中图分类号:R914.2
引用信息:
[1]陈燕,郝敬来,仇缀百.软药设计[J].中国临床药学杂志,2004(04):254-256.DOI:10.19577/j.cnki.issn10074406.2004.04.028.
2004-07-25
2004-07-25