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肾素-血管紧张素系统(RAS)是人体血压和体液的重要调节系统,该系统的激活可导致高血压及靶器官损害。直接肾素抑制剂作用于RAS系统的起始环节,可明显降低血浆肾素活性和血管紧张素水平。阿利吉仑是首个口服有效的非肽类肾素抑制剂,在降压、改善胰岛素抵抗、抑制靶器官损害等方面疗效好,不良反应较少,是一安全、有效的临床新药。
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基本信息:
DOI:10.19577/j.cnki.issn10074406.2011.06.021
中图分类号:R96
引用信息:
[1]胡晓娜,刘方,保志军.直接肾素抑制剂阿利吉仑的药理作用及临床应用研究进展[J].中国临床药学杂志,2011,20(06):387-390.DOI:10.19577/j.cnki.issn10074406.2011.06.021.
2011-11-25
2011-11-25