中国临床药学杂志

目的观察胰岛素对成人晚发自身免疫性糖尿病(LADA)患者C肽水平的影响。方法LADA患者87例分为2组,A组以口服降糖药物治疗,B组以胰岛素治疗,血糖控制在良好水平[糖化血红蛋白(HbA1c)≤7%],每隔6 mo抽血测0、60、120和180 min C肽水平,计算C肽面积,共观察2 a。结果A、B 2组2 a后分别完成观察46例和32例,A组患者C肽面积于2 a时缓慢下降,B组一直保持治疗前水平,2组比较差异有显著性意义(P<0.05)。结论LADA患者早期采用胰岛素治疗,可有效保持C肽面积,保护胰岛功能。

AIM To observe the offects of insulin on the level of C-peptide of untreated patients with latent autoimmune diabetes in adults(LADA).METHODS Eighty-seven patients of LADA were divided into mainly lower-blood-glucose(oral) medicine therapy group(Group A),mainly insulin therapy group(Group B) and the treatment result was HbA_1c≤7%.The level of C-peptide of blood(0,60,120,and 180 min) was tested every half a year.The area of C-peptide was calculated.RESULTS The level of C-peptide of group A decreased slowly in secend year while group B remained the level before theatment.The difference between the two groups was significant(P<0.05).CONCLUSION The earlier insulin therapy can prevent the level of C-peptide from decreasing and protect insulin function in LADA.