中国临床药学杂志

目的观察防风通圣颗粒联合硫普罗宁治疗非乙醇性脂肪肝的近期临床疗效。方法 72例非乙醇性脂肪肝患者随机平行分为对照组和观察组,各36例。对照组给予硫普罗宁注射液静脉滴注,口服复合维生素B片;观察组给予硫普罗宁注射液静滴,内服防风通圣颗粒。两组均连续用药8周。观察两组的疗效及治疗前后症状及体征、肝功能、血脂、B超肝脏脂肪沉积情况。结果对照组显效率27.8%,总有效率69.4%;观察组分别为55.6%和91.7%。两组比较,差异具有统计学意义(P<0.05)。观察组降酶(ALT、AST)、降血脂(TG、TCH、HDL),改善B超肝脏脂肪沉积,以及改善症状和体征均明显优于对照组(P<0.05或P<0.01)。结论防风通圣颗粒联合硫普罗宁治疗非乙醇性脂肪肝具有较好的近期临床疗效。

AIM To observe the recent clinical curative effect of the combination of Fangfeng Tongsheng pill and tiopronin in the treatment of nonalcoholic fatty liver disease.METHODS Seventy-two patients suffering from nonalcoholic fatty liver disease were randomly and evenly divided into 2 groups control group and observation group,with 36 patients of each group.In the control group,patients were given intravenous injection of tiopronin and vitamin B orally.In the observation group,patients were given intravenous injection of tiopronin and Fangfeng Tongsheng pills orally.Both groups were taken the medicines continuously for 4 weeks.Observations were made on curative effects,symptoms before and after treatments,and the changes of physical signs,liver function,blood fat and B-type ultrasonic inspection of fat deposit in liver of the 2 groups.RESULTS In the control group the efficacy rate was 27.8%and the total effective rate was 72.2%.In the observation group the efficacy rate was 55.6%and the total effective rate was 91.7%.The curative effect of the observation group was better than that of the control group(P<0.05).Compared with the control group, the observation group in reducing enzyme and blood fat,improving B-type ultrasonic inspection of fat deposit in liver and improvement of symptoms and physical signs were evident(P<0.05 or P<0.01).CONCLUSION The combination of Fangfeng Tongsheng pill and tiopronin has an obvious curative effect in treating nonalcoholic fatty liver disease.The effect is much better than that treated by using tiopronin only.