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<正>病毒对抗病素药物产生耐药性的问题越来越被人们所重视.单纯疱疹病毒(HSV)、巨细胞病毒(MV)、水痘带状疱疹病毒(VZV)及流在病毒A(in-fluenza-A)等的感染患者,如用了抗病毒药物治疗后,病情仍难以控制或出现新的损害时,应考虑到耐药性的存在,并立即更换治疗方案,选择适当的替代治疗药物.一些早期的抗病毒药具有令人无法忍受的毒性(如阿糖胞苷和疱疹净),特别是出现三致(致癌、致畸、致突变),因此不能广泛应用.用于预防流感病毒A感染非常有效的金刚烷胺巴也减少应用,1977年阿昔洛韦(acyclovir)的发现,因其对免疫缺陷患者原发及复发的生殖器疱疹、疱疹性脑炎、新生儿疱疹和VZV的感染极为有效而被广泛应用.因此,抗病毒药的耐药性首先出现在那些用阿昔洛韦来治疗的疱疹病毒感染患者中.1 抗疱疹病毒药分类1.1核苷类似物 疱疹净(idoxuridine)、阿糖腺苷
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基本信息:
DOI：10.19577/j.cnki.issn10074406.1998.05.022
中图分类号:R453
引用信息:
[1]孙毅平,汪翼,马沛然.抗病毒药的耐药性和选药[J].中国临床药学杂志,1998(05):248-250.DOI:10.19577/j.cnki.issn10074406.1998.05.022.
1998-10-15
1998-10-15