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2024, 05, v.33 321-333
基于基因变异的呼吸系统疾病多重用药专家共识
基金项目(Foundation): 国家重点研发计划专项课题(编号2020YFC2005500,2020YFC2005502)
邮箱(Email):
DOI: 10.19577/j.1007-4406.2024.05.001
摘要:

呼吸系统疾病患者多药联用非常普遍,受共同的药物代谢酶或转运体影响,多药联用易产生药物相互作用而影响疗效或导致药物不良反应。药物代谢酶和转运体的活性及药物作用靶点的敏感性均会受到遗传因素影响,导致药物疗效存在个体差异,因此,通过检测药物代谢相关基因,结合临床疗效评估,在治疗中进行个体化用药方案调整,已逐渐成为临床多重用药风险防控的重要手段。中华医学会临床药学专科分会组织相关专家,针对呼吸系统疾病多重用药的患者,根据最新的循证医学/药学证据,制定了《基于基因变异的呼吸系统疾病多重用药专家共识》,为临床治疗方案的制定提供证据支持。

Abstract:

Multi-drug combination therapy is frequently used in patients with respiratory diseases. Affected by common drug metabolism enzymes or transporters, multi-drug use is prone to produce drug interactions, which can affect efficacy or lead to adverse drug reactions. The activity of drug metabolism enzymes and transporters and the sensitivity of drug targets are affected by genetic factors, resulting in individual differences in drug efficacy. Therefore, individualized medication regimen adjustment by detecting genes related to drug metabolism combined with clinical efficacy evaluation has gradually become an important means for the risk prevention and control of multi-drug use in clinical multi-disease comorbidities. The Clinical Pharmacy Branch of the Chinese Medical Association organized relevant experts to formulate the Expert Consensus on Multi-drug Use for Respiratory Diseases under the Guidance of Gene Polymorphism based on the latest evidence-based medical or pharmacy results for patients with multiple-drug use for respiratory tract diseases, further promoting its application in the treatment practice of respiratory system clinical diseases, and providing evidence support for medical institutions to make clinical treatment plans.

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基本信息:

DOI:10.19577/j.1007-4406.2024.05.001

中图分类号:R969

引用信息:

[1].基于基因变异的呼吸系统疾病多重用药专家共识[J].中国临床药学杂志,2024,33(05):321-333.DOI:10.19577/j.1007-4406.2024.05.001.

基金信息:

国家重点研发计划专项课题(编号2020YFC2005500,2020YFC2005502)

发布时间:

2024-05-25

出版时间:

2024-05-25

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