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慢性粒细胞白血病(CML)是一种多系血液系统恶性肿瘤。复发转移/不可切除胃肠道间质瘤(GIST)是一类起源于胃肠道间叶组织的实体肿瘤。甲磺酸伊马替尼被批准用于治疗CML和晚期GIST,尽管伊马替尼的疗效获得广泛认可,多种因素仍然会导致其出现不理想的反应或治疗失败。治疗药物浓度监测(TDM)是评估临床疗效和指导个体化给药的重要技术,许多研究显示TDM对酪氨酸激酶抑制剂的临床应用非常有益。因此,就国际和国内现有的临床使用伊马替尼时进行TDM的指南进行综述,总结归纳既已达成共识的伊马替尼TDM推荐意见,为伊马替尼个体化给药方案的实施提供参考。
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基本信息:
DOI:10.19577/j.1007-4406.2022.11.016
中图分类号:R735;R733.72
引用信息:
[1]蔡林璇,陈岷,童荣生,等.伊马替尼用于慢性粒细胞白血病和胃肠道间质瘤的治疗药物监测:国内外相关指南概览[J].中国临床药学杂志,2022,31(11):874-880.DOI:10.19577/j.1007-4406.2022.11.016.
基金信息:
国家重点研发计划(编号2020YFC2005500); 四川省科技厅重点研发计划(编号2019YFS0514); 2021年度个体化药物治疗四川省重点实验室开发课题(编号2021YB02); 2021年四川省干部保健科研课题(编号:川干研2021-238); 2021年希思科临床肿瘤学研究基金会(编号Y-MSDPU2021-0078)
2022-11-25
2022-11-25