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报道多学科会诊(MDT)模式下1例妊娠期乳腺癌化疗患者的药学实践。患者,女性,31岁,因“发现左乳外上方肿块20 d”收治入院,行左侧乳房象限切除术+左侧乳房筋膜组织瓣成形术+左侧腋窝淋巴结清扫术(低位清扫),术后病理报告显示(左乳)乳腺浸润性导管癌。在MDT讨论中,临床药师根据循证医学证据,从化疗方案的选择、预处理策略以及药物不良反应发生后的方案调整等方面提出了明确建议,最终为患者确定了多西他赛注射液联合注射用环磷酰胺的化疗方案,并就多西他赛注射液的预处理方法进行循证与优化。经治疗,患者顺利完成了4个周期化疗,并于妊娠37周6 d经阴道顺产一活婴,母婴结局良好,状况稳定。
Abstract:[1]中华医学会外科学分会乳腺外科学组.中国妊娠期与哺乳期乳腺癌临床实践指南(2022版)[J].中国实用外科杂志, 2022,42(2):146.
[2] National Comprehensive Cancer Network. Clinical practice guidelines in oncology:breast cancer.(version 1,2021)[EB/OL].(2021-01-15)[2024-12-18]. https://www. nccn. org/patients.
[3]中华医学会外科学分会乳腺外科学组.妊娠相关性乳腺癌临床诊治专家共识(2020版)[J/OL].中华临床医师杂志(电子版),2020, 14(5):321.
[4] MURTHY R K, THERIAULT R L, BARNETT C M, et al.Outcomes of children exposed in utero to chemotherapy for breast cancer[J]. Breast Cancer Res, 2014, 16(6):500.
[5] JONES S E, SAVIN M A, HOLMES F A, et al. Phase III trial comparing doxorubicin plus cyclophosphamide with docetaxel plus cyclophosphamide as adjuvant therapy for operable breast cancer[J]. J Clin Oncol, 2006, 24(34):5381.
[6] AMANT F, LOIBL S, NEVEN P, et al. Breast cancer in pregnancy[J]. Lancet, 2012, 379(9815):570.
[7] CLEMONS M, SIMOS D, SIENKIEWICZ M, et al. A prospective multi-centre, randomized study comparing the addition of tapering dexamethasone to other standard of care therapies for taxaneassociated pain syndrome(TAPS)in breast cancer patients[J].Support Care Cancer, 2021, 29(10):5787.
[8] FERRIGNO GUAJARDO A S, VACA-CARTAGENA B F,MAYER E L, et al. Taxanes for the treatment of breast cancer during pregnancy:an international cohort study[J]. J Natl Cancer Inst, 2024, 116(2):239.
[9] LANSINGER O M, BIEDERMANN S, HE Z H, et al. Do steroids matter? A retrospective review of premedication for taxane chemotherapy and hypersensitivity reactions[J]. J Clin Oncol,2021, 39(32):3583.
[10] HAGER A, KONDLE S, AGARWAL A, et al. Comparative study of dexamethasone premedication regimens with docetaxel chemotherapy in early HER-2 positive breast cancer:a safety net hospital experience[J]. J Oncol Pharm Pract, 2025, 31(2):236.
[11] LUGTENBERG R T, DE GROOT S, HOUTSMA D, et al. PhaseⅠstudy to evaluate the safety of reducing the prophylactic dose of dexamethasone around docetaxel infusion in patients with prostate and breast cancer[J]. Cancers, 2023, 15(6):1691.
[12] HSU T, FERGUSSON D, STOBER C, et al. A randomized clinical trial comparing physician-directed or fixed-dose steroid replacement strategies for incomplete dexamethasone dosing prior to docetaxel chemotherapy[J]. Support Care Cancer, 2021,29(6):3113.
基本信息:
DOI:10.19577/j.1007-4406.2025.10.012
中图分类号:R714.2;R737.9;R969
引用信息:
[1]金经,王先利,曾涛.多学科会诊模式下1例妊娠期乳腺癌化疗患者的药学实践[J].中国临床药学杂志,2025,34(10):787-789.DOI:10.19577/j.1007-4406.2025.10.012.
基金信息: