临床药师参与治疗五日热巴尔通体感染性心内膜炎的药学实践Pharmaceutical practice of clinical pharmacists participating in treating Bartonella quintana infective endocarditis
汤迎爽;曹珊珊;吴凡;刘志恒;张娴;李寅;康阿龙;
摘要(Abstract):
报道1例五日热巴尔通体感染性心内膜炎的病例。患者为青年男性,以"间断发热数月"为主诉入院。住院期间行外周血定量宏基因组二代测序检测,提示检出微生物五日热巴尔通体,序列数348,相对丰度93.3%,诊断为五日热巴尔通体感染性心内膜炎。临床药师结合患者实际情况,查阅国内外文献,给予盐酸多西环素片(100 mg,po,q12h)联合硫酸庆大霉素注射液(3 mg·kg-1,iv gtt,qd)抗感染治疗。经治疗,患者各项检查、检验指标均正常,感染得到了有效控制。
关键词(KeyWords): 临床药师;哌拉西林钠他唑巴坦钠;血小板增多;不良反应
基金项目(Foundation):
作者(Authors): 汤迎爽;曹珊珊;吴凡;刘志恒;张娴;李寅;康阿龙;
DOI: 10.19577/j.1007-4406.2022.01.013
参考文献(References):
- [1]谢吉科,马序竹,毛乾泰.临床药师参与治疗粪肠球菌感染心内膜炎的用药分析[J].中国临床药理学杂志,2021,37(11):1430.
- [2]GOULD F K,DENNING D W,ELLIOTT T S J,et al.Guidelines for the diagnosis and antibiotic treatment of endocarditis in adults:a report of the Working Party of the British Society for Antimicrobial Chemotherapy[J].J Antimicrob Chemother,2012,67(2):269.
- [3]王佳,高辉,徐益,等.感染性心内膜炎患者病原菌分布及耐药性分析[J].中国抗生素杂志,2019,44(8):958.
- [4]BIN ABDULHAK A A,BADDOUR L M,ERWIN P J,et al.Global and regional burden of infective endocarditis,1990-2010:a systematic review of the literature[J].Glob Heart,2014,9(1):131.
- [5]ROLAIN J M,LECAM C,RAOULT D.Simplified serological diagnosis of endocarditis due to Coxiella burnetii and Bartonella[J].Clin Diagn Lab Immunol,2003,10(6):1147.
- [6]中华医学会心血管病学分会,中华心血管病杂志编辑委员会.成人感染性心内膜炎预防、诊断和治疗专家共识[J].中华心血管病杂志,2014,42(10):806.
- [7]程军,胡欢,张思明,等.二代测序在检测感染性心内膜炎患者心脏瓣膜组织病原体中的应用[J].中国感染控制杂志,2019,18(4):277.
- [8]《中华传染病杂志》编辑委员会.中国宏基因组学第二代测序技术检测感染病原体的临床应用专家共识[J].中华传染病杂志,2020,38(11):681.
- [9]蔡思诗,杨晔,潘珏,等.瓣膜宏基因二代测序在感染性心内膜炎病原学诊断中的应用[J].中华医院感染学杂志,2020,30(22):3404.
- [10]WILSON M R,NACCACHE S N,SAMAYOA E,et al.Actionable diagnosis of neuroleptospirosis by next-generation sequencing[J].N Engl J Med,2014,370(25):2408.
- [11]MAURIN M,RAOULT D.Bartonella (rochalimaea) Quintana infections[J].Clin Microbiol Rev,1996,9(3):273.
- [12]OKARO U,ADDISU A,CASANAS B,et al.Bartonella species,an emerging cause of blood-culture-negative endocarditis[J].Clin Microbiol Rev,2017,30(3):709.
- [13]FOUCAULT C,BROUQUI P,RAOULT D.Bartonella quintana characteristics and clinical management[J].Emerg Infect Dis,2006,12(2):217.
- [14]戴维·吉尔伯特.热病:桑福德抗微生物治疗指南(第48版)[M].范洪伟,译.北京:中国协和医科大学出版社,2019.
- [15]BADDOUR L M,WILSON W R,BAYER A S,et al.Infective endocarditis in adults:diagnosis,antimicrobial therapy,and management of complications:a scientific statement for healthcare professionals from the American heart association[J].Circulation,2015,132(15):1435.
- [16]ROLAIN J M,BROUQUI P,KOEHLER J E,et al.Recommendations for treatment of human infections caused by Bartonella species[J].Antimicrob Agents Chemother,2004,48(6):1921.
- [17]ANSTEAD G M.The centenary of the discovery of trench fever,an emerging infectious disease of World War 1[J].Lancet Infect Dis,2016,16(8):164.