康帅;胡立;路建;吴城;周红梅;

• 1:浙江省嘉兴学院附属第二医院麻醉科

摘要(Abstract)：

目的观察丙泊酚复合舒芬太尼清醒镇静能否降低鼾症患者胃镜检查中不良反应及术后疲劳综合征(POFS)的发生率。方法共纳入胃镜检查的鼾症患者133例,随机分成清醒镇静组和深度镇静组。清醒镇静组采用丙泊酚复合舒芬太尼麻醉,深度镇静组采用传统丙泊酚麻醉。观察术中、术后不良反应,前者包括缺氧、呛咳、低血压、心动过缓,后者包括眩晕、头痛、恶心、呕吐、视力模糊、幻觉等,计算POFS发生率、初始疲劳评分和POFS持续时间。结果术中,清醒镇静组缺氧发生率显著低于深度镇静组(6.6%vs 19.0%,P <0.05),而呛咳发生率组间差异无统计学意义(29.5%vs 17.2%,P> 0.05)。术后,清醒镇静组恶心发生率显著高于深度镇静组(24.6%vs 10.3%,P <0.05),眩晕发生率也显著高于深度镇静组(36.1%vs 15.5%,P <0.05),而POFS发生率显著低于深度镇静组(18%vs 34.5%,P <0.05),初始疲劳评分也显著低于深度镇静组(4.3±1.5 vs 6.4±1.7,P <0.05)。结论丙泊酚复合舒芬太尼清醒镇静能降低鼾症患者在胃镜检查期间不良反应发生率和POFS发生率及严重程度,是鼾症患者行胃镜检查的良好选择。

关键词(KeyWords)： 胃镜检查;清醒镇静;鼾症;不良反应;疲劳综合征

Abstract:

Keywords:

基金项目(Foundation): 嘉兴市科技计划项目（编号2019AD32148）

作者(Author): 康帅;胡立;路建;吴城;周红梅;

Email:

DOI: 10.19577/j.1007-4406.2021.01.002

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