65例直、结肠癌中BAX基因突变与化疗敏感性关系Association between BAX gene mutations and chemosensitivity in 65 colorectal cancers
翟晓波,陈志东,张毅,陆瑶华,沈炜明
摘要(Abstract)：
目的:找出直、结肠癌中BAX基因突变与抗癌药耐药性之间的关系.方法:用MTT法测定17种常用抗癌药对65例肠癌的体外敏感性,并用聚合酶链反应单链构象多态分析技术检测其BAX基因突变情况,将之分成BAX基因正常组和突变组,并比较两组中抗癌药抑制率大小.结果:BAX基因正常组抗癌药抑制率大于突变组,其中有8种抗癌药两组存在显著差异.结论:当直、结肠癌中存在BAX基因突变时,抗癌药耐药性增加.
关键词(KeyWords)： 抗癌药;肠癌;MTT;化疗敏感性;聚合酶链反应;BAX基因
基金项目(Foundation):
作者(Author): 翟晓波,陈志东,张毅,陆瑶华,沈炜明
DOI: 10.19577/j.cnki.issn10074406.1998.05.008
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