急性冠脉综合征患者中氯吡格雷抵抗的发生率及影响因素Incidence rates of clopidogrel resistance and influential factors in patients with acute coronary syndrome
王明亮;朱毅;甘洁民;
摘要(Abstract)：
目的探讨急性冠状动脉综合征(ACS)患者中氯吡格雷抵抗(CPGR)的发生率及影响因素。方法入选100例拟行经皮冠状动脉介入治疗(PCI)的ACS患者,服用负荷量氯吡格雷(CPG)前、服药后24 h分别采血,利用光比浊法测定血浆二磷酸腺苷(ADP)诱导的血小板聚集率(PA),根据PA抑制程度判断CPGR发生率,并据此分为CPGR组和非CPGR组。对ACS患者临床危险因素与CPGR进行相关分析。结果 100例ACS患者中有23例发生CPGR,CPGR发生率为23%。CPGR组和非CPGR组在基线临床特征和合并用药方面差异均无统计学意义(P>0.05)。但CPGR组基线PA明显低于非CPGR组(P<0.05),基线PA是CPGR的独立预测指标。结论 ACS和PCI术后抗血小板治疗中,部分患者确实存在CPGR现象。基线PA水平对CPGR具有重要的预测价值。
关键词(KeyWords)： 急性冠脉综合征;氯吡格雷;药物抵抗;血小板聚集率;影响因素
基金项目(Foundation):
作者(Authors): 王明亮;朱毅;甘洁民;
DOI: 10.19577/j.cnki.issn10074406.2010.03.002
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